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Castro et al., 2020 - Hcfc1a regulates neural precursor proliferation and asxl1 expression in the developing brain

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Fig. 9

Quantification of the number of NPCs after inhibition of Asxl1 activity. a, b Quantification of the number of Sox2⁺ (a) or EdU (b) positive cells in vehicle treated and larvae treated with LY294002 at 2 days post fertilization (DFP). N = 4 Vehicle Sibling, 6 Vehicle hcfc1a^co60/+ larvae, and 4 LY294002 hcfc1a^co60/+ larvae. ^§p = 0.000168, ^§§p = 2.08852E−09, ^§§§p = 0.000153. ^◊p = 7.22142E−07, ^◊◊p = 0.000997, ^◊◊◊p = 0.00014. All error bars represent standard error of the mean. chcfc1a^co60/+ larvae and their wildtype siblings (Sibling) were treated at 24 h intervals with 12 μM LY294002 until 5 DPF and then total RNA was isolated from brain homogenates. Quantitative real time PCR was performed to test the expression of sox2, asxl1, and cyclin E (ccne1). N = 10/group/biological replicate. Error bars represent standard error of the mean. *p < 0.05

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Neurosci.