Gene

asxl1

ID

ZDB-GENE-091116-9

Name

ASXL transcriptional regulator 1

Symbol

asxl1 Nomenclature History

Previous Names

si:dkey-202m22.4

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Acts upstream of or within monocyte proliferation and regulation of neutrophil differentiation. Predicted to be located in nucleus. Is expressed in head kidney; immature eye; lateral mesoderm; and nervous system. Used to study myeloproliferative neoplasm. Human ortholog(s) of this gene implicated in SM-AHNMD; acute myeloid leukemia; chronic myelomonocytic leukemia; myelodysplastic syndrome; and myelofibrosis. Orthologous to human ASXL1 (ASXL transcriptional regulator 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 13 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With asxl1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
myelodysplastic syndrome	Alliance	Myelodysplastic syndrome, somatic	614286
		Bohring-Opitz syndrome	605039

Associated With asxl1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
myeloproliferative neoplasm	asxl1^zdf34/+	standard conditions	Gjini et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR007759	ASXL, HARE-HTH domain
Domain	IPR026905	Protein ASX-like, PHD domain
Domain	IPR028020	ASX, DEUBAD domain
Domain	IPR044867	DEUBAD domain
Family	IPR024811	Polycomb protein ASX/ASX-like