Gene

asxl1

ID
ZDB-GENE-091116-9
Name
ASXL transcriptional regulator 1
Symbol
asxl1 Nomenclature History
Previous Names
  • si:dkey-202m22.4
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have chromatin binding activity and peroxisome proliferator activated receptor binding activity. Predicted to be involved in animal organ morphogenesis and positive regulation of transcription by RNA polymerase II. Predicted to colocalize with nuclear chromatin. Used to study myeloproliferative neoplasm. Human ortholog(s) of this gene implicated in SM-AHNMD; acute myeloid leukemia; chronic myelomonocytic leukemia; myelodysplastic syndrome; and myelofibrosis. Orthologous to human ASXL1 (ASXL transcriptional regulator 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With asxl1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bohring-Opitz syndrome 605039
Myelodysplastic syndrome, somatic 614286
Associated With asxl1 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR007759 ASXL, HARE-HTH domain
Domain IPR026905 Protein ASX-like, PHD domain
Domain IPR028020 ASX, DEUBAD domain
Domain IPR044867 DEUBAD domain
Family IPR024811 Polycomb protein ASX/ASX-like
Domain Details Per Protein
Protein Length ASX, DEUBAD domain ASXL, HARE-HTH domain DEUBAD domain Polycomb protein ASX/ASX-like Protein ASX-like, PHD domain
UniProtKB:A0A8M9PX23 1619
UniProtKB:A0A8M9PE54 1670
UniProtKB:A0A8M2B9F5 1659
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA asxl1-201 (1) Ensembl 4806 nt
mRNA asxl1-202 (1) Havana 5881 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations