IMAGE

Fig. 7

ID
ZDB-IMAGE-180711-31
Genes
Source
Figures for Selland et al., 2018
Image
Figure Caption

Fig. 7

RA signaling is unaffected by the loss of PG1 hox genes.

The expression of aldh1a2 at 70% epiboly is unchanged in paralog group 1 mutants (B, C, D) as compared to wildtype (A). The loss of hoxb1b causes a downregulation of cyp26c1 (hoxb1b−/−: 16/17 embryos, hoxb1a−/−;hoxb1b−/−: 7/7 embryos)(G, H) and cyp26b1 (hoxb1b−/−: 20/20 embryos, hoxb1a−/−;hoxb1b−/−: 8/8 embryos)(K, L) in r4. hoxb1a−/− mutants show no reduction in the expression of cyp26c1 (F) or cyp26b1 (J) in r4. The expression of RA dependent genes, hoxd4a (M-P) and meis3 (Q-T) are unaffected by the loss of paralog group 1 hox genes. All embryos have been genotyped for hoxb1asa1191 and hoxb1bua1006. All images are dorsal views, (A-D) anterior to the top, 70% epiboly, (E-T) anterior to the left, 4 somites.

Figure Data
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Mechanisms of Development, 150, Selland, L.G., Koch, S., Laraque, M., Waskiewicz, A.J., Coordinate regulation of retinoic acid synthesis by pbx genes and fibroblast growth factor signaling by hoxb1b is required for hindbrain patterning and development, 28-41, Copyright (2018) with permission from Elsevier. Full text @ Mech. Dev.