Gene
meis3
- ID
- ZDB-GENE-010406-2
- Name
- myeloid ecotropic viral integration site 3
- Symbol
- meis3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Enables sequence-specific DNA binding activity. Involved in hindbrain development and positive regulation of transcription by RNA polymerase II. Acts upstream of or within enteric nervous system development; exocrine pancreas development; and neural crest cell migration involved in autonomic nervous system development. Located in cytoplasm and nucleus. Is expressed in several structures, including fin bud; mesoderm; neural keel; neural plate; and posterior neural tube. Orthologous to several human genes including MEIS3 (Meis homeobox 3) and MEIS3P2 (Meis homeobox 3 pseudogene 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 32 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la019490Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027665Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-meis3 | N/A | (2) |
| MO2-meis3 | N/A | diIorio et al., 2007 |
| MO3-meis3 | N/A | Manfroid et al., 2007 |
| MO4-meis3 | N/A | Bessa et al., 2008 |
| MO5-meis3 | N/A | Melvin et al., 2013 |
| MO6-meis3 | N/A | Amin et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox protein PKNOX/Meis, N-terminal | Homeodomain | KN homeodomain | Three Amino acid Loop Extension (TALE) homeobox |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q90ZE3 | InterPro | 415 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-527K2 | ZFIN Curated Data | |
| Contains | SNP | rs3728692 | ZFIN Curated Data | |
| Contains | SNP | rs3728693 | ZFIN Curated Data | |
| Contains | SNP | rs3728694 | ZFIN Curated Data | |
| Contains | SNP | rs3728695 | ZFIN Curated Data | |
| Encodes | EST | fb82a09 | Rauch et al., 2003 | |
| Encodes | EST | fc22g05 | ZFIN Curated Data | |
| Encodes | EST | ibd3530 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:86567 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131778 (1) | 2341 nt | ||
| Genomic | GenBank:CU655967 (2) | 32090 nt | ||
| Polypeptide | UniProtKB:Q90ZE3 (1) | 415 aa |
No data available
- Prummel, K.D., Crowell, H.L., Nieuwenhuize, S., Brombacher, E.C., Daetwyler, S., Soneson, C., Kresoja-Rakic, J., Kocere, A., Ronner, M., Ernst, A., Labbaf, Z., Clouthier, D.E., Firulli, A.B., Sánchez-Iranzo, H., Naganathan, S.R., O'Rourke, R., Raz, E., Mercader, N., Burger, A., Felley-Bosco, E., Huisken, J., Robinson, M.D., Mosimann, C. (2022) Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma. Nature communications. 13:1677
- Lin, Z., Luo, M., Zhou, B., Liu, Y., Sun, H. (2021) CFTR regulates embryonic T lymphopoiesis via Wnt signaling in zebrafish. Immunology Letters. 234:47-53
- Lu, C.J., Fan, X.Y., Guo, Y.F., Cheng, Z.C., Dong, J., Chen, J.Z., Li, L.Y., Wang, M.W., Wu, Z.K., Wang, F., Tong, X.J., Luo, L.F., Tang, F.C., Zhu, Z.Y., Zhang, B. (2018) Single-cell analyses identify distinct and intermediate states of zebrafish pancreatic islet development. Journal of molecular cell biology. 11(6):435-447
- Selland, L.G., Koch, S., Laraque, M., Waskiewicz, A.J. (2018) Coordinate regulation of retinoic acid synthesis by pbx genes and fibroblast growth factor signaling by hoxb1b is required for hindbrain patterning and development. Mechanisms of Development. 150:28-41
- Uribe, R.A., Hong, S.S., Bronner, M.E. (2017) Retinoic acid temporally orchestrates colonization of the gut by vagal neural crest cells. Developmental Biology. 433(1):17-32
- Ott, E., Wendik, B., Srivastava, M., Pacho, F., Töchterle, S., Salvenmoser, W., Meyer, D. (2016) Pronephric tubule morphogenesis in zebrafish depends on Mnx mediated repression of irx1b within the intermediate mesoderm. Developmental Biology. 411(1):101-14
- Xiao, C., Gao, L., Hou, Y., Xu, C., Chang, N., Wang, F., Hu, K., He, A., Luo, Y., Wang, J., Peng, J., Tang, F., Zhu, X., Xiong, J.W. (2016) Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish. Nature communications. 7:13787
- Amin, S., Donaldson, I.J., Zannino, D.A., Hensman, J., Rattray, M., Losa, M., Spitz, F., Ladam, F., Sagerström, C., Bobola, N. (2015) Hoxa2 selectively enhances Meis binding to change a branchial arch ground state. Developmental Cell. 32:265-77
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Uribe, R.A., Bronner, M.E. (2015) Meis3 is required for neural crest invasion of the gut during zebrafish enteric nervous system development. Molecular biology of the cell. 26(21):3728-40
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