ZFIN Image: Venero Galanternik M. et al., 2016, Fig. 4

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Figure Caption

Fig. 4

Dkk1b is able to inhibit Wnt/β-catenin and Fgf signaling in the absence of glypican4. (A-D) Expression of the Wnt/β-catenin target lef1 in non-transgenic siblings (A) and glypican4^fr6 mutants (B) in the leading region of the primordium. (C-D) After heat shock, 28–30 hpf transgenic siblings (C) and glypican4^fr6 mutants (D) lose expression of lef1 indicating that Dkk1b is functional and inhibits Wnt target genes. (E-H) The Fgf target pea3 is expressed in the trailing region of the primordium in non-transgenic control siblings (E) and glypican4^fr6 mutants (F) and is downregulated after induction of Dkk1-GFP in both backgrounds indicating that the inhibition of Wnt targets results in the loss of Fgf signaling (G-H).

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Acknowledgments

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Reprinted from Developmental Biology, 419(2), Venero Galanternik M., Lush, M.E., Piotrowski, T., Glypican4 Modulates Lateral Line Collective Cell Migration Non Cell-Autonomously, 321-335, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.