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Fig. 4
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Fig. 4
Loss of Med12 activity leads to reduction in tbx2b expression and FGF signaling activation. Compared to WT, the expression of tbx2b was decreased in med12 mutants at 14 hpf (A, A′); while the expression of flh remained unchanged (B, B′). The activation of FGF signaling was also disrupted in med12 mutants at 1 dpf as shown by Tg[dusp6:d2eGFP] transgene expression (D, D′; projection neurons labeled in red by Tg[HuC:Kaede]) and dpERK staining (E, E′), while the expression of the ligand fgf8a was unaffected (C, C′).
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Reprinted from Developmental Biology, 385(1), Wu, S.Y., de Borsetti, N.H., Bain, E.J., Bulow, C.R., and Gamse, J.T., Mediator subunit 12 coordinates intrinsic and extrinsic control of epithalamic development, 13-22, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.