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ZIRC
ZFIN ID: ZDB-GENE-990726-27
Gene Name: T-box transcription factor 2b
Gene Symbol: tbx2b    Nomenclature History

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Previous Names: tbx-c, tbx2, tbxc, fby, hm:zeh1581 (1), lor, zeh1581

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; cell migration involved in gastrulation; and photoreceptor cell fate specification. Predicted to localize to the nucleus. Is expressed in several structures, including heart; immature eye; mesoderm; nervous system; and pronephros. Orthologous to human TBX2 (T-box transcription factor 2).
Genome Resources: Alliance (1), Gene:30253 (1), Ensembl(GRCz11):ENSDARG00000006120 (1)
GENE EXPRESSION
All Expression Data: 84 figures from 58 publications
Directly Submitted Expression Data: 6 figures (11 images) from Thisse et al., 2004 [MGC:55196]
Wild-type Stages, Structures: Blastula:30%-epiboly (4.66h-5.25h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
c144 Point Mutation Unknown Premature Stop ENU
la019280Tg Transgenic Insertion Unknown Unknown DNA
la019281Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • p25bbtl Unknown Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tbx2 N/A 3
    MO1-tbx2b N/A 6
    MO2-tbx2b N/A 1
    MO3-tbx2b N/A 1
    MO4-tbx2b N/A 8
    MO5-tbx2b N/A 3
    MO7-tbx2b N/A 1
    DISEASE ASSOCIATED WITH tbx2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Vertebral anomalies and variable endocrine and T-cell dysfunction 618223
    DISEASE ASSOCIATED WITH tbx2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axial mesoderm development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 37)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tbx2b-201 (1)    Ensembl 2616
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM tbx2b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(myl7:tbx2b-2A-GFP) myl7 GFPtbx2b Danio rerio 1 3
    Tg(tbx2b:DsRed) tbx2b DsRed Danio rerio 1 3
    Tg(tbx2b:GFP) tbx2b GFP Danio rerio 1 3
    Tg(tbx2b:mCherry) tbx2b mCherry Danio rerio 1 3
    MARKER RELATIONSHIPS
    tbx2bContained in: [BAC] CH211-229G11 (1) (order this)
    tbx2bEncodes: [EST] zeh1581
    [cDNA] MGC:55196 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131051 (1) 2628bp
    Genomic GenBank:AL954322 (1) 149122bp
    Select Tool
    Polypeptide UniProtKB:Q7ZTU9 (1) 687aa
    Sequence Clusters UniGene:8233 (1)
    Sequence Information (all 18)
    ORTHOLOGY for tbx2b (Chr: 15)
    CITATIONS (130)