ZFIN Gene: tbx2b

ZFIN ID: ZDB-GENE-990726-27

ZFIN ID: ZDB-GENE-990726-27

Gene Name:

T-box transcription factor 2b

Gene Symbol:

tbx2b Nomenclature History

Previous Names:

tbx-c, tbx2, tbxc, fby, hm:zeh1581 (1), lor, zeh1581

Gene Type:

protein_coding_gene

Location:

Chr: 15 Mapping Details/Browsers

Description:

Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; cell migration involved in gastrulation; and photoreceptor cell fate specification. Predicted to localize to nucleus. Is expressed in several structures, including heart; immature eye; mesoderm; nervous system; and pronephros. Human ortholog(s) of this gene implicated in vertebral anomalies and variable endocrine and T-cell dysfunction. Orthologous to human TBX2 (T-box transcription factor 2).

Genome Resources:

Alliance (1), Gene:30253 (1), Ensembl(GRCz11):ENSDARG00000006120 (1)

GENE EXPRESSION
All Expression Data:	85 figures from 59 publications
Directly Submitted Expression Data:	6 figures (11 images) from Thisse et al., 2004 [MGC:55196]
Wild-type Stages, Structures:	Blastula:30%-epiboly (4.66h-5.25h) to Adult (90d-730d, breeding adult)
	anterior lateral line placode anterior neural keel atrioventricular canal myocardium atrioventricular canal atrioventricular ring atrium axial chorda mesoderm axial mesoderm brain bulbus arteriosus cardiac ventricle chordo neural hinge anterior region chordo neural hinge medial region corpuscles of Stannius cranial ganglion sensory neuron cranial ganglion diencephalon neuron diencephalon postero-dorsal region diencephalon epiphysis eye fin forebrain neural keel head heart heart tube hypaxial myotome region immature eye intermediate mesoderm posterior region mesenchyme pectoral fin myocardium neural plate neural rod neural tube neuron notochord distal region notochord notochord posterior region optic cup dorsal region optic primordium optic vesicle otic placode otic vesicle parapineal organ pectoral fin pectoral fin bud pectoral fin field periderm pharyngeal arch 3-7 skeleton pineal complex anterior-most region pineal complex left side pineal complex posterior region pineal complex posterior lateral line placode posterior pancreatic bud posterior pronephric duct presumptive diencephalon dorsal region presumptive diencephalon presumptive neural retina pronephric distal early tubule pronephric distal late tubule pronephric duct pronephros posterior region retina retinal ganglion cell layer retinal inner nuclear layer retinal neural layer Rohon-Beard neuron sinoatrial valve basal region sinoatrial valve sinus venosus spinal cord spinal cord interneuron spinal cord neural rod neuron tail bud ventral region trigeminal ganglion trigeminal placode unspecified ventricular myocardium whole organism
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
c144	Point Mutation	Unknown	Premature Stop	ENU
la019280Tg	Transgenic Insertion	Unknown	Unknown	DNA
la019281Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
p25bbtl	Unknown	Unknown	Unknown	ENU

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-tbx2	N/A	3
MO1-tbx2b	N/A	6
MO2-tbx2b	N/A	1
MO3-tbx2b	N/A	1
MO4-tbx2b	N/A	8
MO5-tbx2b	N/A	3
MO7-tbx2b	N/A	1
MO8-tbx2b	N/A	1

PHENOTYPE

Data:

35 figures from 20 publications

Observed in:

DISEASE ASSOCIATED WITH tbx2b HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
vertebral anomalies and variable endocrine and T-cell dysfunction	Alliance	Vertebral anomalies and variable endocrine and T-cell dysfunction	618223

DISEASE ASSOCIATED WITH tbx2b VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	axial mesoderm development (more)
Cellular Component	nucleus (more)
Molecular Function	DNA binding (more)

GO Terms (all 34)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	tbx2b-201 (1)	2616	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM tbx2b

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
Tg(myl7:tbx2b-2A-GFP)	myl7	GFP, tbx2b	Danio rerio	1	3
Tg(tbx2b:DsRed)	tbx2b	DsRed	Danio rerio	1	3
Tg(tbx2b:GFP)	tbx2b	GFP	Danio rerio	1	3
Tg(tbx2b:mCherry)	tbx2b	mCherry	Danio rerio	1	3

MARKER RELATIONSHIPS

tbx2b Contained in:	[BAC] CH211-229G11 (1)
tbx2b Encodes:	[EST] zeh1581 [cDNA] MGC:55196 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_131051 (1)	2628 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:AL954322 (1)	149122 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q7ZTU9 (1)	687 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 17)

ORTHOLOGY for tbx2b ( Chr: 15 )

CITATIONS (136)

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