ZFIN Image: Breau et al., 2013, Fig. 5

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Figure Caption

Fig. 5

Hoxb8a is a target of Wnt signaling and is sufficient to down-regulate cxcr7b upon inhibition of Wnt pathway. ISH showing expression of (A and B) lef1, (C and D) hoxb8a, (E and F) hoxb6a, (G and H) cxcr4b, and (I and J) cxcr7b in hsp70:dkk1gfp embryos and control heat-shocked siblings. Embryos were heat-shocked at 24 hpf and fixed at 30 hpf. ISH to detect expression of (K) cxcr4b and (M) cxcr7b followed by Myc immunostaining (brown) in hsp70:dkk1gfp/cldnb4.2:gal4 x UAS:Hoxb8aMT embryos. ISH to detect expression of (L) cxcr4b and (N) cxcr7b in hsp70:dkk1gfp/cldnb4.2:gal4 x UAS:Hoxb8aVP16 embryos. The number of embryos indicated are pooled from three independent experiments and they are as follows: A, 57; B, 60; C, 62; D, 58; E, 41; F, 63; G, 66; H, 40; I, 67; J, 67; K, 23; L, 55; M, 38; N, 46. (Scale bar: 25 µm.)

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Expression / Labeling details

Acknowledgments

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