ZFIN Image: Shin et al., 2012, Fig. 3

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Figure Caption

Fig. 3

sox17 and sox32 are expressed in the forming liver of wild-type and wnt2bb mutant embryos. (A-F) sox17 (A-C, arrows) and sox32 (D-F, arrows) are re-expressed in the endoderm at 48 and 72 but not 25 hpf. Dorsal views, anterior to the left. (G-J) sox17 in situ hybridization combined with anti-GFP immunostaining in Tg(gutGFP)^s854 embryos reveals sox17 expression (red) in the liver (brackets) and later in the gallbladder (I, arrowhead). At 48 hpf, most of the hepatic bud tissue (brackets) in wnt2bb mutants expressed sox17 (J). Ventral views, anterior up. (K-R) Hepatic sox17 and sox32 expression was absent in Wnt/β-catenin signaling deficient embryos (N and R), whereas it was present in wnt2bb mutants (M and Q) andTg(hs:dkk1-GFP) embryos heat-shocked at 18 hpf (L and P). Dorsal views, anterior to the left. Scale bars, 100 µm.

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Acknowledgments

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Reprinted from Mechanisms of Development, 128(11-12), Shin, D., Weidinger, G., Moon, R.T., and Stainier, D.Y., Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver, 525-535, Copyright (2012) with permission from Elsevier. Full text @ Mech. Dev.