ZFIN Image: Li et al., 2014, Fig. 4

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Fig. 4

mecom knockdown leads to the formation of a reduced DL segment. (A) WISH using distal segment markers showed a 3-somite reduction in DL region by 24 hpf. The distal segments and pronephros ducts were labeled by clcnk. Expression of slc12a1 and slc12a3 marked the DE and DL respectively. Pronephros segment boundaries were evaluated relative to the somites, which were shown by smyhc1 expression (red). The reduced DL could be ameliorated by co-injection of mecom morpholino and mecom cRNA. (B) Schematic depiction of distal segment alterations, with DL domains highlighted in orchid. Abbreviations: DE (distal early), DL (distal late), and PD (pronephric duct).

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Acknowledgments

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Reprinted from Developmental Biology, 386(1), Li, Y., Cheng, C.N., Verdun, V.A., and Wingert, R.A., Zebrafish nephrogenesis is regulated by interactions between retinoic acid, mecom, and Notch signaling, 111-122, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.