Gene
clcnk
- ID
- ZDB-GENE-040426-1379
- Name
- chloride channel K
- Symbol
- clcnk Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have voltage-gated chloride channel activity. Predicted to be involved in chloride transport. Predicted to localize to integral component of plasma membrane. Human ortholog(s) of this gene implicated in Bartter disease type 3; Bartter disease type 4b; Gitelman syndrome; hypertension; and sensorineural hearing loss. Is expressed in renal system. Orthologous to human CLCNKA (chloride voltage-gated channel Ka) and CLCNKB (chloride voltage-gated channel Kb).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64141 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Pérez-Rius et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Bartter disease type 3 | Alliance | Bartter syndrome, type 3 | 607364 |
| Bartter disease type 4b | Alliance | Bartter syndrome, type 4b, digenic | 613090 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CBS domain | CBS domain superfamily | Chloride channel, core | Chloride channel, voltage gated | Voltage-gated chloride channel |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PKM9
|
724 | |||||
|
UniProtKB:Q7T329
|
693 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available