Gene
slc12a3
- ID
- ZDB-GENE-030131-9505
- Name
- solute carrier family 12 member 3
- Symbol
- slc12a3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Is predicted to enable sodium:potassium:chloride symporter activity. Involved in cell volume homeostasis; inorganic ion homeostasis; and inorganic ion transmembrane transport. Acts upstream of or within cloaca development and pronephric duct morphogenesis. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including blood; intermediate mesoderm; opercular flap; pleuroperitoneal region; and scale. Human ortholog(s) of this gene implicated in Gitelman syndrome and essential hypertension. Orthologous to human SLC12A3 (solute carrier family 12 member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 83 figures from 36 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7153737 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Abu Seman et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Gitelman syndrome | Alliance | Gitelman syndrome | 263800 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Amino acid permease, N-terminal | Amino acid permease/ SLC12A domain | SLC12A transporter, C-terminal | SLC12A transporter family | Thiazide-sensitive Na-K-Cl co-transporter |
---|---|---|---|---|---|---|
UniProtKB:A9JRV0
|
711 | |||||
UniProtKB:Q1LX46
|
1012 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
slc12a3-201
(1)
|
3792 nt | |
ncRNA |
slc12a3-002
(1)
|
560 nt |
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab3-slc12a3 | polyclonal | Rabbit |
|
1 | |||
Ab2-slc12a3 | polyclonal | Rabbit |
|
1 | |||
Ab1-slc12a3 | polyclonal | Rabbit |
|
1 |
Plasmids
No data available