header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-030131-9505
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.
Gene Name: solute carrier family 12 member 3
Gene Symbol: slc12a3    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: NCCT (1), si:ch211-122c9.4, wu:fj83c03 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have sodium:potassium:chloride symporter activity. Involved in cloaca development and pronephric duct morphogenesis. Predicted to localize to the apical plasma membrane. Human ortholog(s) of this gene implicated in Gitelman syndrome and essential hypertension. Is expressed in several structures, including blood; intermediate mesoderm; opercular flap; pleuroperitoneal region; and scale. Orthologous to human SLC12A3 (solute carrier family 12 member 3).
Genome Resources: Alliance (1),  Gene:565439 (1),  Ensembl(GRCz11):ENSDARG00000013855 (2)
GENE EXPRESSION
All Expression Data: 78 figures from 33 publications
Directly Submitted Expression Data: 7 figures (11 images) from Thisse et al., 2004 [IMAGE:7153737]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb343 Small Deletion Exon 1 Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
    • sa8732 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-slc12a3 1
    MO1-slc12a3 N/A 1
    PHENOTYPE
    Data: Fig. 4 from Abu Seman et al., 2014
    Observed in:
    DISEASE ASSOCIATED WITH slc12a3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Gitelman syndrome Alliance Gitelman syndrome 263800
    DISEASE ASSOCIATED WITH slc12a3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cloaca development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function cation:chloride symporter activity (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002948 (1)
  • InterPro:IPR004841 (1)
  • InterPro:IPR004842 (1)
  • InterPro:IPR013612 (1)
  • InterPro:IPR018491 (1)
  • Pfam:PF00324 (1)
  • Pfam:PF03522 (1)
  • Pfam:PF08403 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA slc12a3-201 (1)    Ensembl 3792
    Select Tool
    ncRNA slc12a3-002 (1)    Ensembl 560
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab3-slc12a3 polyclonal Rabbit IHC 1
    Ab2-slc12a3 polyclonal Rabbit IHC 1
    Ab1-slc12a3 polyclonal Rabbit IHC 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slc12a3
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(slc12a3:mCherry,myl7:EGFP) myl7,  slc12a3 EGFP,  mCherry Danio rerio 1 2
    MARKER RELATIONSHIPS
    slc12a3 Contained in: [BAC] CH211-122C9 (1) (order this)
    slc12a3 Encodes: [EST] fj83c03, IMAGE:7153737 (1) (order this)
    [cDNA] MGC:174979 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001045080 (1) 3792 bp
    Select Tool
    Genomic GenBank:BX470170 (1) 108112 bp
    Select Tool
    Polypeptide UniProtKB:Q1LX46 (1) 1012 aa
    Select Tool
    Sequence Clusters UniGene:119111 (1)
    Sequence Information (all 16)
    ORTHOLOGY for slc12a3 ( Chr: 18 )
    CITATIONS (70)