Gene

slc12a3

ID
ZDB-GENE-030131-9505
Name
solute carrier family 12 member 3
Symbol
slc12a3 Nomenclature History
Previous Names
  • NCCT (1)
  • si:ch211-122c9.4
  • wu:fj83c03 (1)
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Is predicted to enable sodium:potassium:chloride symporter activity. Involved in cell volume homeostasis; inorganic ion homeostasis; and inorganic ion transmembrane transport. Acts upstream of or within cloaca development and pronephric duct morphogenesis. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including blood; intermediate mesoderm; opercular flap; pleuroperitoneal region; and scale. Human ortholog(s) of this gene implicated in Gitelman syndrome and essential hypertension. Orthologous to human SLC12A3 (solute carrier family 12 member 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
83 figures from 36 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Abu Seman et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With slc12a3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Gitelman syndrome Alliance Gitelman syndrome 263800
Associated With slc12a3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004841 Amino acid permease/ SLC12A domain
Domain IPR013612 Amino acid permease, N-terminal
Domain IPR018491 SLC12A transporter, C-terminal
Family IPR002948 Thiazide-sensitive Na-K-Cl co-transporter
Family IPR004842 SLC12A transporter family
Domain Details Per Protein
Protein Length Amino acid permease, N-terminal Amino acid permease/ SLC12A domain SLC12A transporter, C-terminal SLC12A transporter family Thiazide-sensitive Na-K-Cl co-transporter
UniProtKB:A9JRV0 711
UniProtKB:Q1LX46 1012
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-slc12a3 polyclonal Rabbit
  • IHC
1
Ab2-slc12a3 polyclonal Rabbit
  • IHC
1
Ab1-slc12a3 polyclonal Rabbit
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations