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ZIRC
ZFIN ID: ZDB-GENE-030131-9505
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Gene Name: solute carrier family 12 member 3
Gene Symbol: slc12a3
Sequence Ontology ID : SO:0000704

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Previous Names: NCCT (1), si:ch211-122c9.4, wu:fj83c03 (1)

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(Including Attributions)
Location: Chr: 18 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have sodium:potassium:chloride symporter activity; involved in cloaca development and pronephric duct morphogenesis; predicted to localize to the apical plasma membrane; orthologous to  ...
GENE EXPRESSION
All Expression Data: 67 figures from 30 publications
Directly Submitted Expression Data: 7 figures (11 images) from Thisse et al., 2004 [IMAGE:7153737]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb343 Small Deletion Exon 1 Unknown CRISPR
sa8732 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Targeting reagents:
    PHENOTYPE
    Data: Fig. 4 from Abu Seman et al., 2014
    Observed in:
    DISEASE ASSOCIATED WITH slc12a3 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Gitelman syndrome Gitelman syndrome 263800
    DISEASE ASSOCIATED WITH slc12a3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cloaca development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function cation:chloride symporter activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002948 (1)
  • InterPro:IPR004841 (1)
  • InterPro:IPR004842 (1)
  • InterPro:IPR013612 (1)
  • InterPro:IPR018491 (1)
    		•
  • Pfam:PF00324 (1)
  • Pfam:PF03522 (1)
  • Pfam:PF08403 (1)
    		•
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA slc12a3-002 (1) 560
    Select Tool
    mRNA slc12a3-201 (1) 3792
    Select Tool
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM slc12a3
    MARKER RELATIONSHIPS
    slc12a3Contained in: [BAC] CH211-122C9 (1) (order this)
    slc12a3Encodes: [EST] fj83c03, IMAGE:7153737 (1) (order this)
    [cDNA] MGC:174979 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001045080 (1) 3792bp
    Select Tool
    Genomic GenBank:BX470170 (1) 108112bp
    Select Tool
    Polypeptide UniProtKB:Q1LX46 (1) 1012aa
    Select Tool
    Sequence Clusters UniGene:119111 (1)
    Sequence Information (all 16)
    OTHER slc12a3 GENE PAGES
  • Alliance (1)
  • Gene:565439 (1)
  • VEGA:OTTDARG00000012991 (1)
  • Ensembl(GRCz11):ENSDARG00000013855 (2)
    • ORTHOLOGY for slc12a3 (Chr: 18)
    CITATIONS (65)