ZFIN Image: Superina et al., 2014, Fig. 6

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Fig. 6 Canonical Wnt signaling is upregulated in MZjek;. (A–F) Whole-mount in situ hybridization (WISH) for dorsal organizer genes goosecoid (A,B; gsc; N=26,23) and chordin (C,D; chd; N=20,21), and ventral gene vox (E,F; N=15,18) at shield stage. Dorsal (D) and Ventral (V) orientation indicated in panel A. Embryos are viewed from the animal pole with dorsal to the right. (G–L) WISH of axin2 (G,H; N=12,8), sp5 (I,J; N=18,11), and sp5l (K,L; N=9,8) at 12 SS. Gene expression appears to be most dramatically upregulated in the tailbud (arrowheads). Anterior (A) and Posterior (P) extents are as indicated in panel G.

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Acknowledgments

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Reprinted from Developmental Biology, 387(2), Superina, S., Borovina, A., and Ciruna, B., Analysis of maternal-zygotic ugdh mutants reveals divergent roles for HSPGs in vertebrate embryogenesis and provides new insight into the initiation of left-right asymmetry, 154-166, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.