ZFIN Image: Webb et al., 2011, Fig. 6

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Figure Caption

Fig. 6

her8a expression is independent of endogenous Notch signaling in the early neural plate. Dorsal views of flat-mounted embryos analyzed at the 3-somite stage for the expression of the genes indicated. A-F. Ectopic Notch activation (injection of capped NICD mRNA) abolished neurog1 expression (B) and activates her8a (D) and her4.1 (F) compared to non-injected embryos (ctrl). G-J′. Notch blockade (incubation in the gamma-secretase inhibitor DAPT) increases neurog1 expression within proneural clusters (H) but leaves her8a expression intact (J) at early neural plate stages compared to embryos treated with a vehicle only (ctrl). G′-J′ are high magnification views of the areas boxed in G-J.

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Dev. Biol.