IMAGE

Fig. 1

ID
ZDB-IMAGE-090831-32
Genes
Source
Figures for Hammond et al., 2009
Image
Figure Caption

Fig. 1 Expression of dzip1, sufu and hip in the otic region of 26hpf wild-type, ptc1-/-; ptc2-/- double mutants and smo-/- single mutants. (A–H) Levels of dzip1 and sufu are unaltered in ptc1-/-; ptc2-/- and smo-/- embryos, in which Hh signalling is severely up- and down-regulated, respectively. (I–L) hip expression is strongly up-regulated in ptc1-/-; ptc2-/- embryos and down-regulated in smo-/- embryos. For comparison, each set of mutants and siblings (A–L) were stained in the same well and photographed using the same light intensity. (M and N) Hand cut transverse section (M) and lightly stained whole-mount (N) ptc1-/-; ptc2-/- specimens showing that, although highly up-regulated, hip expression remains regionalised in the ptc1-/-; ptc2-/- embryo. All panels, except M, are dorsal views of the hindbrain and otic region of whole-mount 26hpf embryos. Anterior is to the top except in panels K and L, where anterior is to the left, and panel M, which is a transverse hand cut section at the level of the otic vesicle, dorsal to top. Abbreviations: g, statoacoustic ganglion; n, notochord; nt, neural tube; o, otic vesicle.

Figure Data
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Gene expression patterns : GEP, 9(6), Hammond, K.L., and Whitfield, T.T., Expression of zebrafish hip: response to Hedgehog signalling, comparison with ptc1 expression, and possible role in otic patterning, 391-396, Copyright (2009) with permission from Elsevier. Full text @ Gene Expr. Patterns