Gene
sufu
- ID
- ZDB-GENE-030131-6223
- Name
- suppressor of fused homolog (Drosophila)
- Symbol
- sufu Nomenclature History
- Previous Names
-
- Su(fu) (1)
- dre
- dreumes
- fi39e05
- sb:eu762
- wu:fi39e05
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Exhibits zinc ion binding activity. Involved in several processes, including lens development in camera-type eye; negative regulation of smoothened signaling pathway; and smoothened signaling pathway. Localizes to Hedgehog signaling complex. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Orthologous to human SUFU (SUFU negative regulator of hedgehog signaling).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu762 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 12 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Joubert syndrome 32 | Alliance | Joubert syndrome 32 | 617757 |
| medulloblastoma | Alliance | {Medulloblastoma} | 155255 |
| nevoid basal cell carcinoma syndrome 2 | Alliance | Basal cell nevus syndrome 2 | 620343 |
| {Meningioma, familial, susceptibility to} | 607174 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR020941 | Suppressor of fused-like domain |
| Domain | IPR024314 | Suppressor of fused C-terminal |
| Family | IPR007768 | Suppressor of fused |
| Family | IPR016591 | Suppressor of fused, eukaryotic |
| Homologous_superfamily | IPR037181 | Suppressor of fused, N-terminal |
| Homologous_superfamily | IPR038489 | Suppressor of fused, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | Suppressor of fused | Suppressor of fused C-terminal | Suppressor of fused, C-terminal domain superfamily | Suppressor of fused, eukaryotic | Suppressor of fused-like domain | Suppressor of fused, N-terminal |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZVZ9
|
485 | ||||||
|
UniProtKB:A9JRW8
|
472 |
Interactions and Pathways
Plasmids
No data available