Gene
hhip
- ID
- ZDB-GENE-030131-4827
- Name
- hedgehog interacting protein
- Symbol
- hhip Nomenclature History
- Previous Names
-
- Hip (1)
- fd99f01
- uki
- ukkie
- wu:fc52e12
- wu:fd99f01
- zgc:153478
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have catalytic activity. Involved in fin development; negative regulation of muscle organ development; and negative regulation of smoothened signaling pathway. Localizes to intrinsic component of plasma membrane. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Is expressed in several structures, including axis; mesoderm; muscle cell; nervous system; and pharyngeal arch. Orthologous to human HHIP (hedgehog interacting protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR012938 | Glucose/Sorbosone dehydrogenase |
| Domain | IPR013111 | EGF-like domain, extracellular |
| Homologous_superfamily | IPR011041 | Soluble quinoprotein glucose/sorbosone dehydrogenase |
| Homologous_superfamily | IPR011042 | Six-bladed beta-propeller, TolB-like |
Domain Details Per Protein
| Protein | Length | EGF-like domain | EGF-like domain, extracellular | Glucose/Sorbosone dehydrogenase | Six-bladed beta-propeller, TolB-like | Soluble quinoprotein glucose/sorbosone dehydrogenase |
|---|---|---|---|---|---|---|
|
UniProtKB:A1A5I0
|
693 |
Interactions and Pathways
Plasmids
No data available