ZFIN Image: Londin et al., 2005, Fig. 5

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Figure Caption

Fig. 5 FGF signaling represses BMP transcription. Real-time PCR analysis of XFD (A and B) and Δ-FGFR-4 (C and D)-microinjected wild-type embryos during late blastula and early gastrula stages. The fold change (y-axis) of the markers bmp2, bmp4, and bmp7 is set relative to control (GFP)-injected embryos. XFD- and Δ-FGFR-4-injected embryos show an increase BMP transcript levels during late blastula stages. (E–H) RNA in situ hybridization of bmp2 expression in control (E and F)- and XFD-injected wild-type embryos (G and H). In XFD-injected embryos, the bmp2 expression domain extends into the dorsal ectoderm. Panels E and G are lateral views of shield stage embryos and F and H are animal pole views of the same embryos.

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Acknowledgments

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Reprinted from Developmental Biology, 279(1), Londin, E.R., Niemiec, J., and Sirotkin, H.I., Chordin, FGF signaling, and mesodermal factors cooperate in zebrafish neural induction, 1-19, Copyright (2005) with permission from Elsevier. Full text @ Dev. Biol.