Gene
krt5
- ID
- ZDB-GENE-991110-23
- Name
- keratin 5
- Symbol
- krt5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of skin epidermis. Acts upstream of or within fin regeneration. Predicted to be located in intermediate filament. Predicted to be active in keratin filament. Is expressed in several structures, including EVL; epidermal cell; integument; oral region; and periderm. Human ortholog(s) of this gene implicated in several diseases, including Dowling-Degos disease; epidermolysis bullosa simplex (multiple); hypotrichosis (multiple); ichthyosis (multiple); and palmoplantar keratosis (multiple). Orthologous to several human genes including KRT8 (keratin 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77647 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb695 | Allele with one insertion | Exon 2 | Unknown | CRISPR | |
| sa29880 | Allele with one point mutation | Unknown | Missense, Splice Site | ENU | |
| sa31083 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37628 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa43920 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-krt5 | (2) | |
| CRISPR2-krt5 | (2) | |
| CRISPR3-krt5 | Zebrafish Nomenclature Committee | |
| MO1-krt5 | N/A | Pei et al., 2007 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Dowling-Degos disease | Alliance | Dowling-Degos disease 1 | 179850 |
| epidermolysis bullosa simplex with mottled pigmentation | Alliance | Epidermolysis bullosa simplex 2F, with mottled pigmentation | 131960 |
| Epidermolysis bullosa simplex 2A, generalized severe | 619555 | ||
| Epidermolysis bullosa simplex 2B, generalized intermediate | 619588 | ||
| Epidermolysis bullosa simplex 2C, localized | 619594 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Intermediate filament protein, conserved site | Intermediate filament, rod domain | Keratin, type II | Keratin type II head |
|---|---|---|---|---|---|---|
| UniProtKB:Q6P3K5 | InterPro | 553 | ||||
| UniProtKB:A0A8M6YXS6 | InterPro | 554 | ||||
| UniProtKB:F1QV31 | InterPro | 566 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-krt5 | polyclonal | IgG | Rabbit |
|
Thermo Scientific Pierce Protein Research Products
|
2 |
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Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-2.3krt5:RFP) |
|
| 1 | (3) | |
| Tg2(krt5:EGFP) |
|
| 2 | (4) | |
| Tg(krt5:cdx1b-EGFP) |
|
| 1 | (3) | |
| Tg(krt5:EGFP) |
|
| 1 | (5) | |
| Tg(krt5:GAL4-ERT2-VP16,myl7:ECFP) |
|
| 1 | (3) | |
| Tg(krt5:GAL4FF) |
|
| 1 | (6) | |
| Tg(krt5:GAL4-VP16,14xUAS:smo-EGFP) |
|
| 1 | (3) | |
| Tg(krt5:h2az2a-mCherry) |
|
| 1 | (2) | |
| Tg(krt5:LIFEACT-GFP) |
|
| 1 | (2) | |
| Tg(krt5:LIFEACT-mRuby) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-188C24 | ZFIN Curated Data | |
| Encodes | EST | fb02h09 | ZFIN Curated Data | |
| Encodes | EST | fj02d02 | ||
| Encodes | EST | fk78b12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77647 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131156 (1) | 2403 nt | ||
| Genomic | GenBank:BX119982 (1) | 210702 nt | ||
| Polypeptide | UniProtKB:F1QV31 (1) | 566 aa |
- Rayamajhi, D., Ege, M., Ukhanov, K., Ringers, C., Zhang, Y., Jung, I., D'Gama, P.P., Li, S.S., Cosacak, M.I., Kizil, C., Park, H.C., Yaksi, E., Martens, J.R., Brody, S.L., Jurisch-Yaksi, N., Roy, S. (2024) The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation. PLoS Biology. 22:e3002468e3002468
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Charlie-Silva, I., Feitosa, N.M., Pontes, L.G., Fernandes, B.H., Nóbrega, R.H., Gomes, J.M.M., Prata, M.N.L., Ferraris, F.K., Melo, D.C., Conde, G., Rodrigues, L.F., Aracati, M.F., Corrêa-Junior, J.D., Manrique, W.G., Superio, J., Garcez, A.S., Conceição, K., Yoshimura, T.M., Núñez, S.C., Eto, S.F., Fernandes, D.C., Freitas, A.Z., Ribeiro, M.S., Nedoluzhko, A., Lopes-Ferreira, M., Borra, R.C., Barcellos, L.J.G., Perez, A.C., Malafaia, G., Cunha, T.M., Belo, M.A.A., Galindo-Villegas, J. (2022) Plasma proteome responses in zebrafish following λ-carrageenan-Induced inflammation are mediated by PMN leukocytes and correlate highly with their human counterparts. Frontiers in immunology. 13:1019201
- Ge, G., Long, Y., Song, G., Li, Q., Cui, Z., Yan, H. (2022) Transcriptomic Profiling Revealed Signaling Pathways Associated with the Spawning of Female Zebrafish under Cold Stress. International Journal of Molecular Sciences. 23(14):
- Ho, M., Thompson, B., Fisk, J.N., Nebert, D.W., Bruford, E.A., Vasiliou, V., Bunick, C.G. (2022) Update of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders. Human genomics. 16:1
- Rosa, J.B., Nassman, K.Y., Sagasti, A. (2022) Sensory axons induce epithelial lipid microdomain remodeling and determine the distribution of junctions in the epidermis. Molecular biology of the cell. 34(1):ar5
- Metikala, S., Casie Chetty, S., Sumanas, S. (2021) Single-cell transcriptome analysis of the zebrafish embryonic trunk. PLoS One. 16:e0254024
- Carroll, S.H., Macias Trevino, C., Li, E.B., Kawasaki, K., Myers, N., Hallett, S.A., Alhazmi, N., Cotney, J., Carstens, R.P., Liao, E.C. (2020) An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in vertebrates. Development (Cambridge, England). 147(24):
- Han, C.R., Holmsen, E., Carrington, B., Bishop, K., Zhu, Y.J., Starost, M., Meltzer, P., Sood, R., Liu, P., Cheng, S.Y. (2020) Generation of novel genetic models to dissect resistance to thyroid hormone receptor alpha in zebrafish. Thyroid : official journal of the American Thyroid Association. 30(2):314-328
- Paudel, Y.N., Kumari, Y., Abidin, S.A.Z., Othman, I., Shaikh, M.F. (2020) Pilocarpine Induced Behavioral and Biochemical Alterations in Chronic Seizure-Like Condition in Adult Zebrafish. International Journal of Molecular Sciences. 21(7):
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