Gene

krt5

ID
ZDB-GENE-991110-23
Name
keratin 5
Symbol
krt5 Nomenclature History
Previous Names
  • ckii (1)
  • wu:fb02h09 (1)
  • wu:fj02d02
  • wu:fk78b12 (1)
  • zfCKII
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Involved in fin regeneration. Predicted to localize to keratin filament. Is expressed in EVL; epidermal cell; eye; integument; and periderm. Human ortholog(s) of this gene implicated in several diseases, including Dowling-Degos disease; Meesmann corneal dystrophy 2; epidermolysis bullosa simplex (multiple); ichthyosis (multiple); and palmoplantar keratosis (multiple). Orthologous to several human genes including KRT5 (keratin 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
16 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With krt5 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Dowling-Degos disease Alliance Dowling-Degos disease 1 179850
epidermolysis bullosa simplex Alliance Epidermolysis bullosa simplex, recessive 1 601001
epidermolysis bullosa simplex Dowling-Meara type Alliance Epidermolysis bullosa simplex, Dowling-Meara type 131760
epidermolysis bullosa simplex generalized type Alliance Epidermolysis bullosa simplex, Koebner type 131900
epidermolysis bullosa simplex localized type Alliance Epidermolysis bullosa simplex, Weber-Cockayne type 131800
epidermolysis bullosa simplex with mottled pigmentation Alliance Epidermolysis bullosa simplex-MP 131960
Epidermolysis bullosa simplex-MCR 609352
Associated With krt5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018039 Intermediate filament protein, conserved site
Domain IPR032444 Keratin type II head
Domain IPR039008 Intermediate filament, rod domain
Family IPR003054 Keratin, type II
Homologous_superfamily IPR042180 Intermediate filament, rod domain, coil 1B
Domain Details Per Protein
Protein Length Intermediate filament protein, conserved site Intermediate filament, rod domain Intermediate filament, rod domain, coil 1B Keratin, type II Keratin type II head
UniProtKB:E9QBD7 226
UniProtKB:F1R5A5 560
UniProtKB:F1QV31 566
UniProtKB:E9QFT4 201
UniProtKB:Q9PUB5 558
UniProtKB:Q9YH66 111
UniProtKB:Q6P3K5 553
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-krt5 polyclonal IgG Rabbit
  • WB
Thermo Scientific Pierce Protein Research Products
2
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations