Gene

krt5

ID

ZDB-GENE-991110-23

Name

keratin 5

Symbol

krt5 Nomenclature History

Previous Names

ckii (1)
wu:fb02h09 (1)
wu:fj02d02
wu:fk78b12 (1)
zfCKII

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Involved in fin regeneration. Predicted to localize to keratin filament. Human ortholog(s) of this gene implicated in several diseases, including Dowling-Degos disease; epidermolysis bullosa simplex (multiple); epidermolytic hyperkeratosis; ichthyosis (multiple); and palmoplantar keratosis (multiple). Is expressed in EVL; epidermal cell; eye; integument; and periderm. Orthologous to several human genes including KRT5 (keratin 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

22 figures from 14 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:77647 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With krt5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Dowling-Degos disease	Alliance	Dowling-Degos disease 1	179850
epidermolysis bullosa simplex with mottled pigmentation	Alliance	Epidermolysis bullosa simplex 2F, with mottled pigmentation	131960
		Epidermolysis bullosa simplex 2A, generalized severe	619555
		Epidermolysis bullosa simplex 2B, generalized intermediate	619588
		Epidermolysis bullosa simplex 2C, localized	619594
		Epidermolysis bullosa simplex 2D, generalized, intermediate or severe, autosomal recessive	619599
		Epidermolysis bullosa simplex 2E, with migratory circinate erythema	609352

Associated With krt5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018039	Intermediate filament protein, conserved site
Domain	IPR032444	Keratin type II head
Domain	IPR039008	Intermediate filament, rod domain
Family	IPR003054	Keratin, type II