Gene
cyt1
- ID
- ZDB-GENE-991008-6
- Name
- type I cytokeratin, enveloping layer
- Symbol
- cyt1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable structural molecule activity. Acts upstream of or within cell migration involved in gastrulation. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Is expressed in EVL; embryonic structure; epidermis; epithelium; and periderm. Human ortholog(s) of this gene implicated in several diseases, including ectodermal dysplasia (multiple); focal nonepidermolytic palmoplantar keratoderma 1; pachyonychia congenita; steatocystoma multiplex; and white sponge nevus 2. Orthologous to several human genes including KRT13 (keratin 13); KRT14 (keratin 14); and KRT15 (keratin 15).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Pei et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-cyt1 | N/A | Pei et al., 2007 |
| MO2-cyt1 | N/A | Pei et al., 2007 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Intermediate filament, rod domain | Keratin, type I |
|---|---|---|---|---|
| UniProtKB:Q9PWD8 | InterPro | 429 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(cyt1:GFP) |
|
| 1 | (2) | |
| Tg(cyt1:map2k2a_S219D-GFP) |
|
| 1 | Chou et al., 2015 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-113D7 | ZFIN Curated Data | |
| Encodes | EST | fb34e10 | ZFIN Curated Data | |
| Encodes | EST | fc04b06 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:77350 | ZFIN Curated Data | |
| Has Artifact | EST | fa10g10 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131107 (1) | 1403 nt | ||
| Genomic | GenBank:BX323079 (2) | 165200 nt | ||
| Polypeptide | UniProtKB:Q9PWD8 (1) | 429 aa |
No data available
- Baniel, A., Ziv, L., Ben-Moshe, Z., Sarig, O., Mohamad, J., Peled, A., Rechavi, G., Gothilf, Y., Sprecher, E. (2022) Cutaneous and Developmental Effects of CARD14 Overexpression in Zebrafish. Biomedicines. 10(12):
- Spreafico, M., Cafora, M., Bragato, C., Capitanio, D., Marasca, F., Bodega, B., De Palma, C., Mora, M., Gelfi, C., Marozzi, A., Pistocchi, A. (2021) Targeting HDAC8 to ameliorate skeletal muscle differentiation in Duchenne muscular dystrophy. Pharmacological research. 170:105750
- Chestnut, B., Casie Chetty, S., Koenig, A.L., Sumanas, S. (2020) Single-cell transcriptomic analysis identifies the conversion of zebrafish Etv2-deficient vascular progenitors into skeletal muscle. Nature communications. 11:2796
- Zhang, X., Zhou, Q., Li, X., Zou, W., Hu, X. (2020) Integrating omics and traditional analyses to profile the synergistic toxicity of graphene oxide and triphenyl phosphate. Environmental pollution (Barking, Essex : 1987). 263:114473
- Cokus, S.J., De La Torre, M., Medina, E.F., Rasmussen, J.P., Ramirez-Gutierrez, J., Sagasti, A., Wang, F. (2019) Tissue-Specific Transcriptomes Reveal Gene Expression Trajectories in Two Maturing Skin Epithelial Layers in Zebrafish Embryos. G3 (Bethesda). 9(10):3439-3452
- Parolini, M., Bini, L., Magni, S., Rizzo, A., Ghilardi, A., Landi, C., Armini, A., Del Giacco, L., Binelli, A. (2018) Exposure to cocaine and its main metabolites altered the protein profile of zebrafish embryos. Environmental pollution (Barking, Essex : 1987). 232:603-614
- Chou, C.M., Chen, Y.C., Su, S., Chen, G.D., Huang, K.Y., Lien, H.W., Huang, C.J., Cheng, C.H. (2015) Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish. Journal of Biomedical Science. 22:102
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Liu, L., Xu, Y., Xu, L., Wang, J., Wu, W., Xu, L., Yan, Y. (2015) Analysis of differentially expressed proteins in zebrafish (Danio rerio) embryos exposed to chlorpyrifos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 167C:183-189
- Chen, C.H., Lin, D.S., Cheng, C.W., Lin, C.J., Lo, Y.K., Yen, C.C., Lee, A.Y., Hsiao, C.D. (2014) Cdc6 cooperates with c-Myc to promote genome instability and EMT in zebrafish. Oncotarget. 5(15):6300-11
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