Gene
mylpfa
- ID
- ZDB-GENE-990712-15
- Name
- myosin light chain, phosphorylatable, fast skeletal muscle a
- Symbol
- mylpfa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Involved in actin-myosin filament sliding and muscle tissue morphogenesis. Acts upstream of or within skeletal muscle tissue development. Predicted to be part of myosin complex. Predicted to be active in cytoplasm. Is expressed in caudal fin; esophagus; musculature system; segmental plate; and somite. Used to study distal arthrogryposis type 1A. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C. Orthologous to human MYL11 (myosin light chain 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 47 figures from 36 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb46 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Chong et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| distal arthrogryposis type 1C | Alliance | Arthrogryposis, distal, type 1C | 619110 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| distal arthrogryposis type 1A | mylpfaoz43/oz43 (AB) | standard conditions | Chong et al., 2020 |
| distal arthrogryposis type 1A | mylpfaoz30/oz30 (AB) | standard conditions | Chong et al., 2020 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | Myosin regulatory light chain |
|---|---|---|---|---|---|
|
UniProtKB:O93409
|
169 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mylpfa-201
(1)
|
Ensembl | 1,471 nt | ||
| mRNA |
mylpfa-202
(1)
|
Ensembl | 1,304 nt |
Interactions and Pathways
No data available
Plasmids
No data available