Gene

th2

ID

ZDB-GENE-050201-1

Name

tyrosine hydroxylase 2

Symbol

th2 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Enables tryptophan 5-monooxygenase activity. Acts upstream of or within dopamine biosynthetic process and serotonin biosynthetic process. Predicted to be located in cell projection and perinuclear region of cytoplasm. Predicted to be active in axon; cytoplasm; and perikaryon. Is expressed in female organism; head; kidney; liver; and nervous system.

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

38 figures from 27 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With th2 Human Ortholog

No data available

Associated With th2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018301	Aromatic amino acid hydroxylase, iron/copper binding site
Domain	IPR019774	Aromatic amino acid hydroxylase, C-terminal
Domain	IPR041903	Tyrosine 3-monooxygenase, catalytic domain
Domain	IPR049321	Tyrosine 3-monooxygenase-like, ACT domain
Family	IPR001273	Aromatic amino acid hydroxylase
Family	IPR005962	Tyrosine 3-monooxygenase
Family	IPR019773	Tyrosine 3-monooxygenase-like
Homologous_superfamily	IPR036329	Aromatic amino acid monoxygenase, C-terminal domain superfamily
Homologous_superfamily	IPR036951	Aromatic amino acid hydroxylase superfamily
Homologous_superfamily	IPR045865	ACT-like domain