Gene

mdka

ID
ZDB-GENE-990621-1
Name
midkine a
Symbol
mdka Nomenclature History
Previous Names
  • fb05b02
  • fc32h11
  • plei1
  • wu:fb05b02 (1)
  • wu:fc32h11 (1)
  • zgc:86655
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to enable growth factor activity. Acts upstream of with a positive effect on positive regulation of mitotic cell cycle. Acts upstream of or within neural tube formation; regulation of cell cycle; and sensory epithelium regeneration. Located in Golgi apparatus. Is expressed in several structures, including brain; eye; neural tube; neuroectoderm; and paraxial mesoderm. Human ortholog(s) of this gene implicated in brain ischemia. Orthologous to human MDK (midkine).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
26 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mdka Human Ortholog
No data available
Associated With mdka Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR020089 Pleiotrophin/Midkine, N-terminal domain
Domain IPR020090 Pleiotrophin/Midkine, C-terminal domain
Family IPR000762 Midkine heparin-binding growth factor
Homologous_superfamily IPR020091 Pleiotrophin/Midkine disulphide-rich domain superfamily
Homologous_superfamily IPR037122 Pleiotrophin/Midkine, N-terminal domain superfamily
Homologous_superfamily IPR038130 Pleiotrophin/Midkine, C-terminal domain superfamily
Domain Details Per Protein
Protein Length Midkine heparin-binding growth factor Pleiotrophin/Midkine, C-terminal domain Pleiotrophin/Midkine, C-terminal domain superfamily Pleiotrophin/Midkine disulphide-rich domain superfamily Pleiotrophin/Midkine, N-terminal domain Pleiotrophin/Midkine, N-terminal domain superfamily
UniProtKB:Q9W767 146
UniProtKB:A0A1D5NS41 154
UniProtKB:A0A1D5NSV1 110
UniProtKB:E9QIK2 135
UniProtKB:A0A0B5JQ06 148
UniProtKB:A0A1D5NST4 54
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-mdka polyclonal Rabbit
  • IHC
  • WB
3
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations