Gene

acvr1l

ID
ZDB-GENE-990415-9
Name
activin A receptor, type 1 like
Symbol
acvr1l Nomenclature History
Previous Names
  • acvr1
  • alk2 (1)
  • alk8
  • alk8sum
  • etID124543.2 (1)
  • fk50h05
  • laf
  • lost a fin
  • lost-a-fin (2)
  • mfn (1)
  • mini fin (1)
  • wu:fk50h05 (1)
  • zalk8
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; SMAD binding activity; and transforming growth factor beta receptor activity, type I. Involved in several processes, including animal organ development; embryonic morphogenesis; and regionalization. Localizes to BMP receptor complex and cell cortex. Is expressed in brain; ceratobranchial 5 tooth; immature eye; liver; and tooth placode. Human ortholog(s) of this gene implicated in fibrodysplasia ossificans progressiva. Orthologous to human ACVR1 (activin A receptor type 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
27 figures from 16 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With acvr1l Human Ortholog
No data available
Associated With acvr1l Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003605 GS domain
Family IPR000333 Ser/Thr protein kinase, TGFB receptor
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length GS domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site Serine-threonine/tyrosine-protein kinase, catalytic domain Ser/Thr protein kinase, TGFB receptor
UniProtKB:E9QIU0 106
UniProtKB:O73736 506
UniProtKB:Q9DGI6 506
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
AB1-acvr1l polyclonal Rabbit
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations