Gene
thrb
- ID
- ZDB-GENE-990415-268
- Name
- thyroid hormone receptor beta
- Symbol
- thrb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Exhibits nuclear receptor activity. Involved in regulation of transcription, DNA-templated; sensory organ development; and thyroid hormone mediated signaling pathway. Predicted to localize to RNA polymerase II transcription factor complex. Used to study thyroid hormone resistance syndrome. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); cervix uteri carcinoma in situ; renal cell carcinoma; selective pituitary thyroid hormone resistance; and thyroid hormone resistance syndrome. Is expressed in several structures, including brain; eye; heart; liver; and optic vesicle. Orthologous to human THRB (thyroid hormone receptor beta).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 29 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- af109732 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 29 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
selective pituitary thyroid hormone resistance | Alliance | Thyroid hormone resistance, selective pituitary | 145650 |
thyroid hormone resistance syndrome | Alliance | Thyroid hormone resistance | 188570 |
thyroid hormone resistance syndrome | Alliance | Thyroid hormone resistance, autosomal recessive | 274300 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
thyroid hormone resistance syndrome | AB + MO4-thrb | standard conditions | Marelli et al., 2016 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
Family | IPR001723 | Nuclear hormone receptor |
Family | IPR001728 | Thyroid hormone receptor |
Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Thyroid hormone receptor | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2B694
|
479 | ||||||
UniProtKB:S6BPQ3
|
488 | ||||||
UniProtKB:Q9PVE4
|
395 | ||||||
UniProtKB:A0A8M2B654
|
268 | ||||||
UniProtKB:A0A2R8QK91
|
508 | ||||||
UniProtKB:A0A8M9PN36
|
281 | ||||||
UniProtKB:A0A8M9PRA9
|
415 | ||||||
UniProtKB:A0A8M3AK49
|
240 |
Interactions and Pathways
No data available
Plasmids
No data available