Gene
nr2f2
- ID
- ZDB-GENE-990415-252
- Name
- nuclear receptor subfamily 2, group F, member 2
- Symbol
- nr2f2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Acts upstream of with a positive effect on venous endothelial cell fate commitment. Acts upstream of or within brain segmentation and circulatory system development. Predicted to be located in nucleus. Is expressed in several structures, including brain; head; hindbrain neural keel; midbrain neural tube; and neural crest cell. Human ortholog(s) of this gene implicated in 46,XX sex reversal 5. Orthologous to human NR2F2 (nuclear receptor subfamily 2 group F member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 31 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- s80986 (32 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| 46,XX sex reversal 5 | Alliance | 46XX sex reversal 5 | 618901 |
| Congenital heart defects, multiple types, 4 | 615779 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR050274 | Nuclear hormone receptor family NR2 subfamily |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR2 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q91430
|
422 |
Interactions and Pathways
Plasmids
No data available