Gene

brd2a

ID

ZDB-GENE-990415-248

Name

bromodomain containing 2a

Symbol

brd2a Nomenclature History

Previous Names

brd2
fe47f02
fi85h05
ring3 (1)
wu:fe47f02
wu:fi85h05

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Involved in animal organ development and regulation of apoptotic process. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Is expressed in several structures, including digestive system; immature eye; nervous system; neural tube; and pleuroperitoneal region. Orthologous to human BRD2 (bromodomain containing 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 13 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With brd2a Human Ortholog

No data available

Associated With brd2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018359	Bromodomain, conserved site
Domain	IPR001487	Bromodomain
Domain	IPR027353	NET domain
Domain	IPR043508	Brdt, bromodomain, repeat I
Domain	IPR043509	Brdt, bromodomain, repeat II
Family	IPR050935	Bromodomain-containing chromatin reader
Homologous_superfamily	IPR036427	Bromodomain-like superfamily
Homologous_superfamily	IPR038336	NET domain superfamily

Domain Details Per Protein

Protein	Length	Brdt, bromodomain, repeat I	Brdt, bromodomain, repeat II	Bromodomain	Bromodomain, conserved site	Bromodomain-containing chromatin reader	Bromodomain-like superfamily	NET domain	NET domain superfamily
UniProtKB:A8CYR1 InterPro	836
UniProtKB:Q1LWX7 InterPro	832
UniProtKB:A0A8M9P1P2 InterPro	479

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	brd2a-001 (1)	Havana	3,768 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	brd2a-201 (1) Ensembl	Ensembl	4,000 nt	Select Tool ZFIN BLAST
mRNA	brd2a-202 (1) Ensembl	Ensembl	593 nt	Select Tool ZFIN BLAST
mRNA	brd2a-205 (1) Ensembl	Ensembl	3,031 nt	Select Tool ZFIN BLAST
ncRNA	brd2a-004 (1) Ensembl	Ensembl	649 nt	Select Tool ZFIN BLAST
ncRNA	brd2a-005 (1) Ensembl	Ensembl	1,199 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-brd2a	polyclonal	brd2a		Rabbit	IHC WB		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations