apoa1a

ID

ZDB-GENE-990415-14

Name

apolipoprotein A-Ia

Symbol

apoa1a Nomenclature History

Previous Names

apoa1 (1)
apoa
cb49 (1)
etID309895.5 (1)
etID32161.5 (1)
wu:fb33f01 (1)
zgc:103718

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable several functions, including cholesterol transfer activity; high-density lipoprotein particle binding activity; and phosphatidylcholine-sterol O-acyltransferase activator activity. Predicted to be involved in several processes, including acylglycerol homeostasis; cholesterol efflux; and phospholipid efflux. Predicted to act upstream of or within cholesterol biosynthetic process and cholesterol transport. Located in extracellular region. Is expressed in digestive system; ovary; ventral telencephalon; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial hypercholesterolemia; hypolipoproteinemia (multiple); metabolic dysfunction-associated steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (apolipoprotein A1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

28 figures from 19 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb49 (2 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With apoa1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary hypoalphalipoproteinemia 2	Alliance	Hypoalphalipoproteinemia, primary, 2	618463
		Amyloidosis, hereditary systemic 3	620657
		Hypoalphalipoproteinemia, primary, 2, intermediate	619836