Gene

stat3

ID
ZDB-GENE-980526-68
Name
signal transducer and activator of transcription 3 (acute-phase response factor)
Symbol
stat3 Nomenclature History
Previous Names
  • z-Stat3 (1)
  • wu:fc15d02 (1)
  • wu:fl59g06 (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cardiac muscle tissue regeneration; generation of neurons; and receptor signaling pathway via JAK-STAT. Predicted to localize to cytosol and nucleus. Is expressed in blastomere; epidermal superficial stratum; head; immature eye; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3).
Genome Resources
Note
None
Expression
All Expression Data
48 figures from 24 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
12 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With stat3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hyper IgE recurrent infection syndrome 1 Alliance Hyper-IgE recurrent infection syndrome 147060
Autoimmune disease, multisystem, infantile-onset, 1 615952
Associated With stat3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000980 SH2 domain
Domain IPR013799 STAT transcription factor, protein interaction
Domain IPR013800 STAT transcription factor, all-alpha domain
Domain IPR013801 STAT transcription factor, DNA-binding
Domain IPR035855 STAT3, SH2 domain
Family IPR001217 Transcription factor STAT
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR012345 STAT transcription factor, DNA-binding, N-terminal
Homologous_superfamily IPR015988 STAT transcription factor, coiled coil
Homologous_superfamily IPR036535 STAT transcription factor, N-terminal domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length p53-like transcription factor, DNA-binding SH2 domain SH2 domain superfamily STAT3, SH2 domain STAT transcription factor, all-alpha domain STAT transcription factor, coiled coil STAT transcription factor, DNA-binding STAT transcription factor, DNA-binding, N-terminal STAT transcription factor, N-terminal domain superfamily STAT transcription factor, protein interaction Transcription factor STAT
UniProtKB:A0A0R4IGF2 738
UniProtKB:C0SPC7 806
UniProtKB:Q6NV46 786
UniProtKB:A0A1S6L757 718
UniProtKB:O93599 806
UniProtKB:Q7ZTS5 414
UniProtKB:Q9DDJ8 394
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-stat3 polyclonal Rabbit
  • IHC
  • WB
7
Ab7-stat3 polyclonal Rabbit
  • WB
AnaSpec
2
Ab1-stat3 monoclonal IgG1 Mouse
  • IHC
  • WB
MBL International
9
Ab4-stat3 polyclonal Rabbit
AnaSpec
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations