Gene

wnt1

ID
ZDB-GENE-980526-526
Name
wingless-type MMTV integration site family, member 1
Symbol
wnt1 Nomenclature History
Previous Names
  • int-1
  • etID22400.23 (1)
  • sb:eu647
  • zgc:194464
  • zgc:194478
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have cytokine activity and frizzled binding activity. Involved in brain development. Predicted to localize to extracellular space. Is expressed in several structures, including central nervous system; midbrain hindbrain boundary neural keel; neural plate; neural rod; and neural tube. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 15 and osteoporosis. Orthologous to human WNT1 (Wnt family member 1).
Genome Resources
Note
None
Expression
All Expression Data
108 figures from 76 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With wnt1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
osteogenesis imperfecta type 15 Alliance Osteogenesis imperfecta, type XV 615220
{Osteoporosis, early-onset, susceptibility to, autosomal dominant} 615221
Associated With wnt1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018161 Wnt protein, conserved site
Family IPR005817 Wnt
Family IPR009139 Wnt-1 protein
Homologous_superfamily IPR043158 Wnt, C-terminal domain
Domain Details Per Protein
Protein Length Wnt Wnt-1 protein Wnt, C-terminal domain Wnt protein, conserved site
UniProtKB:B3DI55 370
UniProtKB:A0A0B5JWC2 370
UniProtKB:P24257 370
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations