Gene
wnt4
- ID
- ZDB-GENE-980526-352
- Name
- wingless-type MMTV integration site family, member 4
- Symbol
- wnt4 Nomenclature History
- Previous Names
-
- wnt4a
- ZfWnt4 (1)
- zgc:136737
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within several processes, including embryonic morphogenesis; habenula development; and regulation of axon extension involved in axon guidance. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; head; neural rod; neural tube; and reproductive system. Human ortholog(s) of this gene implicated in Mullerian aplasia and hyperandrogenism. Orthologous to human WNT4 (Wnt family member 4).
- Genome Resources
- Note
-
zebrafish wnt4 is the only ortholog of human WNT4 in zebrafish. Teleost wnt4b is a VGD ohnolog gone missing from humans. Teleosts, gar, coelacanth, and some birds and lizard have orthologs of both wnt4a and wnt4b
- Comparative Information
-
- All Expression Data
- 34 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu648 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Mullerian aplasia and hyperandrogenism | Alliance | Mullerian aplasia and hyperandrogenism | 158330 |
| ?SERKAL syndrome | 611812 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Wnt | Wnt-4 protein | Wnt, C-terminal domain | Wnt protein, conserved site |
|---|---|---|---|---|---|
|
UniProtKB:P47793
|
352 | ||||
|
UniProtKB:Q1RLW9
|
352 |
Interactions and Pathways
No data available
Plasmids