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ZIRC
ZFIN ID: ZDB-GENE-980526-306
Gene Name: muscle segment homeobox 3
Gene Symbol: msx3    Nomenclature History

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Previous Names: msx-c, msxc (1), etID309953.13 (1), msh-C, mshC, zgc:86596 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in otic placode formation. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in craniosynostosis and parietal foramina. Is expressed in several structures, including fin bud; germ ring; immature eye; median fin fold; and nervous system. Orthologous to human MSX2 (msh homeobox 2).
Genome Resources: Alliance (1),  Gene:30526 (1),  Ensembl(GRCz11):ENSDARG00000015674 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb246 Indel Exon 1 Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • mn0245Gt Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tud18Gt Transgenic Insertion Exon 1 Unknown DNA
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-msx3 1
    MO1-msx3 N/A 1
    DISEASE ASSOCIATED WITH msx3 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH msx3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process otic placode formation (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 9)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA msx3-201 (1)    Ensembl 2028
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM msx3
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(msx3:DsRed2) msx3 DsRed2 Danio rerio 1 2
    MARKER RELATIONSHIPS
    msx3 Contained in: [BAC] CH211-217G15 (1) (order this), DKEYP-85D1
    msx3 Encodes: [EST] eu507 (1), fc66g03 (1)
    [cDNA] MGC:86596 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131272 (1) 944 bp
    Genomic GenBank:CR589879 201310 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q6IQV1 (1) 274 aa
    Sequence Clusters UniGene:32741 (1)
    Sequence Information (all 24)
    ORTHOLOGY for msx3 ( Chr: 13 )
    CITATIONS (107)