PUBLICATION
Mouse paraxial protocadherin is expressed in trunk mesoderm and is not essential for mouse development
- Authors
- Yamamoto, A., Kemp, C., Bachiller, D., Geissert, D., and De Robertis, E.M.
- ID
- ZDB-PUB-000825-4
- Date
- 2000
- Source
- Genesis (New York, N.Y. : 2000) 27(2): 49-57 (Journal)
- Registered Authors
- De Robertis, Eddy
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Cadherins/biosynthesis*
- Cadherins/genetics
- Embryonic and Fetal Development/genetics
- Gene Expression Regulation, Developmental
- Mesoderm/metabolism*
- Mice
- Molecular Sequence Data
- PubMed
- 10890978 Full text @ Genesis
Citation
Yamamoto, A., Kemp, C., Bachiller, D., Geissert, D., and De Robertis, E.M. (2000) Mouse paraxial protocadherin is expressed in trunk mesoderm and is not essential for mouse development. Genesis (New York, N.Y. : 2000). 27(2):49-57.
Abstract
Summary: Paraxial protocadherin (PAPC) is a cell adhesion molecule that marks cells undergoing convergence-extension cell movements in Xenopus and zebrafish gastrulating embryos. Here a mouse homologue (mpapc) was identified and characterized. During early- to mid-gastrulation, mpapc is expressed in the primitive streak as the trunk mesoderm undergoes morphogenetic cell movements. At head-fold stage mpapc expression becomes localized to paraxial regions in which somites are formed in the segmental plate. At later stages, mpapc displays a complex expression pattern in cerebral cortex, olfactory bulb, inferior colliculus, and in longitudinal stripes in hindbrain. To analyze the effect of the loss of PAPC function during mouse development, a null allele of the mouse papc gene was generated. Homozygous animals show no defects in their skeleton and are viable and fertile.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping