Gene

lamc2

ID
ZDB-GENE-110222-3
Name
laminin, gamma 2
Symbol
lamc2 Nomenclature History
Previous Names
  • sb:eu2427
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to be located in basement membrane and extracellular region. Is expressed in head and pancreatic D cell. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and lung small cell carcinoma. Orthologous to human LAMC2 (laminin subunit gamma 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa19815Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With lamc2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Epidermolysis bullosa, junctional 3A, intermediate 619785
Epidermolysis bullosa, junctional 3B, severe 619786
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Associated With lamc2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000034 Laminin IV
Domain IPR000742 EGF-like domain
Domain IPR002049 Laminin-type EGF domain
Family IPR050440 Laminin/Netrin Extracellular Matrix
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Domain Details Per Protein
Protein Additional Resources Length EGF-like domain Laminin IV Laminin/Netrin Extracellular Matrix Laminin-type EGF domain
UniProtKB:A0A8M1RET4 InterPro 1182
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 2
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA lamc2-201 (1) Ensembl 2,211 nt
mRNA lamc2-202 (1) Ensembl 1,406 nt
mRNA lamc2-203 (1) Ensembl 756 nt
mRNA lamc2-205 (1) Ensembl 1,287 nt
ncRNA lamc2-004 (1) Ensembl 608 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-161L11ZFIN Curated Data
EncodesESTeu2427Thisse et al., 2005
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanLAMC21
Phylogenetic tree (1)
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
MouseLamc21
Phylogenetic tree (1)
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
Citations
1 - 10 of 13
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