Gene

bcl10

ID
ZDB-GENE-100219-2
Name
BCL10 immune signaling adaptor
Symbol
bcl10 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Involved in positive regulation of NF-kappaB transcription factor activity. Localizes to CBM complex. Is expressed in gill; intestine; male organism; and spleen. Human ortholog(s) of this gene implicated in MALT lymphoma; immunodeficiency 37; malignant mesothelioma; and non-Hodgkin lymphoma. Orthologous to human BCL10 (BCL10 immune signaling adaptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With bcl10 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency 37 Alliance ?Immunodeficiency 37 616098
malignant mesothelioma Alliance {Mesothelioma, somatic} 156240
MALT lymphoma Alliance Lymphoma, MALT, somatic 137245
non-Hodgkin lymphoma Alliance {Lymphoma, follicular, somatic} 605027
testicular germ cell cancer Alliance {Male germ cell tumor, somatic} 273300
{Sezary syndrome, somatic}
Associated With bcl10 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001315 CARD domain
Domain IPR042143 BCL10, CARD domain
Family IPR033238 B-cell lymphoma/leukemia 10/E10
Homologous_superfamily IPR011029 Death-like domain superfamily
Domain Details Per Protein
Protein Length B-cell lymphoma/leukemia 10/E10 BCL10, CARD domain CARD domain Death-like domain superfamily
UniProtKB:E7F8A6 241
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-bcl10 polyclonal IgG Rabbit
  • WB
Santa Cruz Biotechnology, Inc.
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations