Gene
hdc
- ID
- ZDB-GENE-080102-5
- Name
- histidine decarboxylase
- Symbol
- hdc Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable histidine decarboxylase activity. Acts upstream of or within chemical synaptic transmission; nervous system development; and response to light stimulus. Located in synapse. Is expressed in brain; caudal hypothalamic zone; hypothalamus; and posterior recess. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; asthma; and rhinitis. Orthologous to human HDC (histidine decarboxylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ct836 | Allele with one deletion | Unknown | Frameshift, Premature Stop | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-hdc | N/A | Sundvik et al., 2011 |
| MO2-hdc | N/A | Sundvik et al., 2011 |
| MO3-hdc | N/A | Sundvik et al., 2011 |
| TALEN1-hdc | (4) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Gilles de la Tourette syndrome | Alliance | {Gilles de la Tourette syndrome, susceptibility to} | 137580 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR021115 | Pyridoxal-phosphate binding site |
| Family | IPR002129 | Pyridoxal phosphate-dependent decarboxylase |
| Family | IPR010977 | Aromatic-L-amino-acid decarboxylase |
| Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| Homologous_superfamily | IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Aromatic-L-amino-acid decarboxylase | Pyridoxal-phosphate binding site | Pyridoxal phosphate-dependent decarboxylase | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain | Pyridoxal phosphate-dependent transferase, small domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BH77 | InterPro | 608 | ||||||
| UniProtKB:A7KBS5 | InterPro | 594 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-histamine | polyclonal | Rabbit |
|
Millipore
|
1 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-398L10 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001102593 (1) | 2765 nt | ||
| Genomic | GenBank:CU611046 (1) | 38469 nt | ||
| Polypeptide | UniProtKB:A0A8M2BH77 (1) | 608 aa |
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Gabellini, C., Pucci, C., De Cesari, C., Martini, D., Di Lauro, C., Digregorio, M., Norton, W., Zippo, A., Sessa, A., Broccoli, V., Andreazzoli, M. (2022) CRISPR/Cas9-Induced Inactivation of the Autism-Risk Gene setd5 Leads to Social Impairments in Zebrafish. International Journal of Molecular Sciences. 24(1):
- Ariyasiri, K., Choi, T.I., Gerlai, R., Kim, C.H. (2021) Acute ethanol induces behavioral changes and alters c-fos expression in specific brain regions, including the mammillary body, in zebrafish. Progress in neuro-psychopharmacology & biological psychiatry. 109:110264
- Baronio, D., Chen, Y.C., Decker, A.R., Enckell, L., Fernández-López, B., Semenova, S., Puttonen, H.A.J., Cornell, R.A., Panula, P. (2021) Vesicular monoamine transporter 2 (SLC18A2) regulates monoamine turnover and brain development in zebrafish. Acta physiologica (Oxford, England). 234(1):e13725
- Baronio, D., Chen, Y.C., Panula, P. (2021) Abnormal brain development of monoamine oxidase mutant zebrafish and impaired social interaction of heterozygous fish. Disease models & mechanisms. 15(3):
- Li, X., Liu, H., Li, D., Lei, H., Wei, X., Schlenk, D., Mu, J., Chen, H., Yan, B., Xie, L. (2021) Dietary Seleno-l-Methionine Causes Alterations in Neurotransmitters, Ultrastructure of the Brain, and Behaviors in Zebrafish (Danio rerio). Environmental science & technology. 55:11894-11905
- Sundvik, M., Puttonen, H., Semenova, S., Panula, P. (2021) The bullies are the leaders of the next generation: inherited aminergic neurotransmitter system changes in socially dominant zebrafish, Danio rerio. Behavioural brain research. 409:113309
- Chen, Y.C., Baronio, D., Semenova, S., Abdurakhmanova, S., Panula, P. (2020) Cerebral Dopamine Neurotrophic Factor regulates multiple neuronal subtypes and behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. 40(32):6146-6164
- Reichmann, F., Rimmer, N., Tilley, C.A., Dalla Vecchia, E., Pinion, J., Al Oustah, A., Carreño Gutiérrez, H., Young, A.M., McDearmid, J.R., Winter, M.J., Norton, W.H. (2020) The zebrafish histamine H3 receptor modulates aggression, neural activity and forebrain functional connectivity. Acta physiologica (Oxford, England). 230(4):e13543
- Schredelseker, T., Veit, F., Dorsky, R.I., Driever, W. (2020) Bsx Is Essential for Differentiation of Multiple Neuromodulatory Cell Populations in the Secondary Prosencephalon. Frontiers in neuroscience. 14:525
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