Gene
hdc
- ID
- ZDB-GENE-080102-5
- Name
- histidine decarboxylase
- Symbol
- hdc Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable histidine decarboxylase activity. Acts upstream of or within chemical synaptic transmission; nervous system development; and response to light stimulus. Located in synapse. Is expressed in brain; caudal hypothalamic zone; hypothalamus; and posterior recess. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; asthma; and rhinitis. Orthologous to human HDC (histidine decarboxylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Gilles de la Tourette syndrome | Alliance | {Gilles de la Tourette syndrome, susceptibility to} | 137580 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR021115 | Pyridoxal-phosphate binding site |
| Family | IPR002129 | Pyridoxal phosphate-dependent decarboxylase |
| Family | IPR010977 | Aromatic-L-amino-acid decarboxylase |
| Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| Homologous_superfamily | IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
| Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
Domain Details Per Protein
| Protein | Length | Aromatic-L-amino-acid decarboxylase | Pyridoxal-phosphate binding site | Pyridoxal phosphate-dependent decarboxylase | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain | Pyridoxal phosphate-dependent transferase, small domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BH77
|
608 | ||||||
|
UniProtKB:A7KBS5
|
594 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-histamine | polyclonal | Rabbit |
|
Millipore
|
1 |
Plasmids
No data available