Gene

fas

ID
ZDB-GENE-061019-2
Name
Fas cell surface death receptor
Symbol
fas Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have tumor necrosis factor-activated receptor activity. Involved in notochord development and positive regulation of apoptotic process. Predicted to localize to CD95 death-inducing signaling complex; external side of plasma membrane; and membrane raft. Is expressed in several structures, including blastoderm; eye; gut; notochord; and ovary. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; leukemia (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor).
Genome Resources
Note
None
Expression
All Expression Data
5 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Ferrari et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fas Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autoimmune lymphoproliferative syndrome Alliance Autoimmune lymphoproliferative syndrome, type IA 601859
autoimmune lymphoproliferative syndrome Alliance {Autoimmune lymphoproliferative syndrome} 601859
Squamous cell carcinoma, burn scar-related, somatic
Associated With fas Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000488 Death domain
Domain IPR001368 TNFR/NGFR cysteine-rich region
Domain IPR033998 Fas receptor, death domain
Domain IPR034055 Tumor necrosis factor receptor 6, N-terminal, teleost
Family IPR008063 Fas receptor
Homologous_superfamily IPR011029 Death-like domain superfamily
Domain Details Per Protein
Protein Length Death domain Death-like domain superfamily Fas receptor Fas receptor, death domain TNFR/NGFR cysteine-rich region Tumor necrosis factor receptor 6, N-terminal, teleost
UniProtKB:F1QG24 293
UniProtKB:Q0PKX5 281
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations