Gene

fas

ID
ZDB-GENE-061019-2
Name
Fas cell surface death receptor
Symbol
fas Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have tumor necrosis factor-activated receptor activity. Involved in notochord development and positive regulation of apoptotic process. Predicted to localize to CD95 death-inducing signaling complex; external side of plasma membrane; and membrane raft. Is expressed in several structures, including blastoderm; eye; gut; notochord; and ovary. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Ferrari et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fas Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autoimmune lymphoproliferative syndrome Alliance Autoimmune lymphoproliferative syndrome, type IA 601859
autoimmune lymphoproliferative syndrome Alliance {Autoimmune lymphoproliferative syndrome} 601859
Squamous cell carcinoma, burn scar-related, somatic
Associated With fas Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000488 Death domain
Domain IPR001368 TNFR/NGFR cysteine-rich region
Domain IPR033998 Fas receptor, death domain
Domain IPR034055 Tumor necrosis factor receptor 6, N-terminal, teleost
Family IPR008063 Fas receptor
Homologous_superfamily IPR011029 Death-like domain superfamily
Domain Details Per Protein
Protein Length Death domain Death-like domain superfamily Fas receptor Fas receptor, death domain TNFR/NGFR cysteine-rich region Tumor necrosis factor receptor 6, N-terminal, teleost
UniProtKB:F1QG24 293
UniProtKB:Q0PKX5 281
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations