Gene
fas
- ID
- ZDB-GENE-061019-2
- Name
- Fas cell surface death receptor
- Symbol
- fas Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable tumor necrosis factor receptor activity. Acts upstream of or within notochord development and positive regulation of apoptotic process. Predicted to be located in membrane. Predicted to be part of CD95 death-inducing signaling complex. Predicted to be active in external side of plasma membrane and membrane raft. Is expressed in several structures, including blastoderm; digestive system; eye; notochord; and ovary. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ferrari et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa11234 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-fas | N/A | Ferrari et al., 2014 |
| MO2-fas | N/A | Ferrari et al., 2014 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autoimmune lymphoproliferative syndrome | Alliance | Autoimmune lymphoproliferative syndrome, type IA | 601859 |
| autoimmune lymphoproliferative syndrome | Alliance | {Autoimmune lymphoproliferative syndrome} | 601859 |
| Squamous cell carcinoma, burn scar-related, somatic |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Death domain | Death-like domain superfamily | Fas receptor | Fas receptor, death domain | TNFR/NGFR cysteine-rich region | Tumor necrosis factor receptor 6, N-terminal, teleost |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QG24 | InterPro | 293 | ||||||
| UniProtKB:A0A8N7UR03 | InterPro | 294 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-116M16 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021467407 (1) | 2020 nt | ||
| Genomic | GenBank:BX511087 (1) | 184012 nt | ||
| Polypeptide | UniProtKB:A0A8N7UR03 (1) | 294 aa |
- Weiss, A., D'Amata, C., Pearson, B.J., Hayes, M.N. (2024) A syngeneic spontaneous zebrafish model of tp53-deficient, EGFRvIII, and PI3KCAH1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo. eLIFE. 13:
- Wu, J., Zhuang, W., Lu, K., Zhang, L., Wang, Y., Chai, F., Liang, X.F. (2024) Study on the Function of Leptin Nutrient Acquisition and Energy Metabolism of Zebrafish (Danio rerio). International Journal of Molecular Sciences. 25(21):
- Katkat, E., Demirci, Y., Heger, G., Karagulle, D., Papatheodorou, I., Brazma, A., Ozhan, G. (2023) Canonical Wnt and TGF-β/BMP signaling enhance melanocyte regeneration but suppress invasiveness, migration, and proliferation of melanoma cells. Frontiers in cell and developmental biology. 11:12979101297910
- Liang, F., Lu, X., Wu, B., Yang, Y., Qin, W. (2023) Nucleolar Protein 56 Deficiency in Zebrafish Leads to Developmental Abnormalities and Anemia via p53 and JAK2-STAT3 Signaling. Biology. 12(4):
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) Deciphering the pathogenesis of retinopathy associated with carnitine palmitoyltransferase I deficiency in zebrafish model. Biochemical and Biophysical Research Communications. 664:100107100-107
- Xie, Z., Lu, G., Zhou, R., Ma, Y. (2022) Thiacloprid-induced hepatotoxicity in zebrafish: Activation of the extrinsic and intrinsic apoptosis pathways regulated by p53 signaling pathway. Aquatic toxicology (Amsterdam, Netherlands). 246:106147
- Zhao, Y., Castro, L.F.C., Monroig, Ó., Cao, X., Sun, Y., Gao, J. (2022) A zebrafish pparγ gene deletion reveals a protein kinase network associated with defective lipid metabolism. Functional & integrative genomics. 22(4):435-450
- Heylen, L., Pham, D.H., De Meulemeester, A.S., Samarut, É., Skiba, A., Copmans, D., Kazwiny, Y., Vanden Berghe, P., de Witte, P.A.M., Siekierska, A. (2021) Pericardial Injection of Kainic Acid Induces a Chronic Epileptic State in Larval Zebrafish. Frontiers in molecular neuroscience. 14:753936
- Sun, S., Cao, X., Castro, L.F.C., Monroig, Ó., Gao, J. (2021) A network-based approach to identify protein kinases critical for regulating srebf1 in lipid deposition causing obesity. Functional & integrative genomics. 21(5-6):557-570
- Xu, H., Wang, G., Chi, Y.Y., Kou, Y.X., Li, Y. (2021) Expression profiling and functional characterization of the duplicated Oxr1b gene in zebrafish. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 39:100857
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