Gene
fas
- ID
- ZDB-GENE-061019-2
- Name
- Fas cell surface death receptor
- Symbol
- fas Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have transmembrane signaling receptor activity. Involved in notochord development and positive regulation of apoptotic process. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); cystic fibrosis; leukemia (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Is expressed in several structures, including blastoderm; eye; gut; notochord; and ovary. Orthologous to human FAS (Fas cell surface death receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ferrari et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autoimmune lymphoproliferative syndrome | Alliance | Autoimmune lymphoproliferative syndrome, type IA | 601859 |
| autoimmune lymphoproliferative syndrome | Alliance | {Autoimmune lymphoproliferative syndrome} | 601859 |
| Squamous cell carcinoma, burn scar-related, somatic |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000488 | Death domain |
| Domain | IPR001368 | TNFR/NGFR cysteine-rich region |
| Domain | IPR033998 | Fas receptor, death domain |
| Domain | IPR034055 | Tumor necrosis factor receptor 6, N-terminal, teleost |
| Family | IPR008063 | Fas receptor |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Death domain | Death-like domain superfamily | Fas receptor | Fas receptor, death domain | TNFR/NGFR cysteine-rich region | Tumor necrosis factor receptor 6, N-terminal, teleost |
|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QG24
|
293 | ||||||
|
UniProtKB:A0A8N7UR03
|
294 |
Interactions and Pathways
No data available
Plasmids
No data available