Gene
ihha
- ID
- ZDB-GENE-051010-1
- Name
- Indian hedgehog signaling molecule a
- Symbol
- ihha Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity and patched binding activity. Acts upstream of or within several processes, including enteric nervous system development; intramembranous ossification; and swim bladder morphogenesis. Predicted to be located in several cellular components, including Golgi membrane; endoplasmic reticulum membrane; and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including caudal fin skeleton; cranium; digestive system; pneumatic duct; and swim bladder bud. Human ortholog(s) of this gene implicated in acrocapitofemoral dysplasia; brachydactyly type A1; retinopathy of prematurity; and syndactyly type 1. Orthologous to human IHH (Indian hedgehog signaling molecule).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acrocapitofemoral dysplasia | Alliance | Acrocapitofemoral dysplasia | 607778 |
| brachydactyly type A1 | Alliance | Brachydactyly, type A1 | 112500 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000320 | Hedgehog, N-terminal signalling domain |
| Domain | IPR001767 | Hedgehog protein, Hint domain |
| Domain | IPR003586 | Hint domain C-terminal |
| Domain | IPR003587 | Hint domain N-terminal |
| Family | IPR001657 | Hedgehog protein |
| Family | IPR050387 | Hedgehog Signaling |
| Homologous_superfamily | IPR009045 | Hedgehog signalling/DD-peptidase zinc-binding domain superfamily |
| Homologous_superfamily | IPR036844 | Hint domain superfamily |
| PTM | IPR006141 | Intein N-terminal splicing region |
Domain Details Per Protein
| Protein | Additional Resources | Length | Hedgehog, N-terminal signalling domain | Hedgehog protein | Hedgehog protein, Hint domain | Hedgehog Signaling | Hedgehog signalling/DD-peptidase zinc-binding domain superfamily | Hint domain C-terminal | Hint domain N-terminal | Hint domain superfamily | Intein N-terminal splicing region |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A3KNS3 | InterPro | 413 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| antisense |
ottdart00000059270
(1)
|
Ensembl | 1,666 nt | ||
| mRNA |
ihha-201
(1)
|
Ensembl | 1,600 nt |
Interactions and Pathways
No data available
Plasmids
No data available