Gene
ihha
- ID
- ZDB-GENE-051010-1
- Name
- Indian hedgehog signaling molecule a
- Symbol
- ihha Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Is predicted to enable calcium ion binding activity and patched binding activity. Involved in cell fate specification and regulation of gene expression. Acts upstream of or within several processes, including enteric nervous system development; intramembranous ossification; and swim bladder morphogenesis. Predicted to be located in plasma membrane. Is expressed in several structures, including caudal fin skeleton; cranium; digestive system; pneumatic duct; and swim bladder bud. Human ortholog(s) of this gene implicated in acrocapitofemoral dysplasia; brachydactyly type A1; retinopathy of prematurity; and syndactyly type 1. Orthologous to human IHH (Indian hedgehog signaling molecule).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acrocapitofemoral dysplasia | Alliance | Acrocapitofemoral dysplasia | 607778 |
| brachydactyly type A1 | Alliance | Brachydactyly, type A1 | 112500 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000320 | Hedgehog, N-terminal signalling domain |
| Domain | IPR001767 | Hedgehog protein, Hint domain |
| Domain | IPR003586 | Hint domain C-terminal |
| Domain | IPR003587 | Hint domain N-terminal |
| Family | IPR001657 | Hedgehog protein |
| Homologous_superfamily | IPR009045 | Hedgehog signalling/DD-peptidase zinc-binding domain superfamily |
| Homologous_superfamily | IPR036844 | Hint domain superfamily |
| PTM | IPR006141 | Intein N-terminal splicing region |
Domain Details Per Protein
| Protein | Length | Hedgehog, N-terminal signalling domain | Hedgehog protein | Hedgehog protein, Hint domain | Hedgehog signalling/DD-peptidase zinc-binding domain superfamily | Hint domain C-terminal | Hint domain N-terminal | Hint domain superfamily | Intein N-terminal splicing region |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A3KNS3
|
413 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| antisense |
ottdart00000059270
(1)
|
1666 nt | |
| mRNA |
ihha-201
(1)
|
1600 nt |
Interactions and Pathways
No data available
Plasmids
No data available