Gene

ihha

ID
ZDB-GENE-051010-1
Name
Indian hedgehog signaling molecule a
Symbol
ihha Nomenclature History
Previous Names
  • hh[a] (1)
  • hha
  • qhh (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity and patched binding activity. Involved in several processes, including intramembranous ossification; osteoblast differentiation; and swim bladder morphogenesis. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in acrocapitofemoral dysplasia; brachydactyly type A1; and retinopathy of prematurity. Is expressed in several structures, including caudal fin skeleton; cranium; digestive system; pneumatic duct; and swim bladder bud. Orthologous to human IHH (Indian hedgehog signaling molecule).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
26 figures from 16 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
21 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ihha Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acrocapitofemoral dysplasia Alliance Acrocapitofemoral dysplasia 607778
brachydactyly type A1 Alliance Brachydactyly, type A1 112500
Associated With ihha Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000320 Hedgehog, N-terminal signalling domain
Domain IPR001767 Hedgehog protein, Hint domain
Domain IPR003586 Hint domain C-terminal
Domain IPR003587 Hint domain N-terminal
Family IPR001657 Hedgehog protein
Homologous_superfamily IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain superfamily
Homologous_superfamily IPR036844 Hint domain superfamily
PTM IPR006141 Intein N-terminal splicing region
Domain Details Per Protein
Protein Length Hedgehog, N-terminal signalling domain Hedgehog protein Hedgehog protein, Hint domain Hedgehog signalling/DD-peptidase zinc-binding domain superfamily Hint domain C-terminal Hint domain N-terminal Hint domain superfamily Intein N-terminal splicing region
UniProtKB:Q4PLX4 413
UniProtKB:B0S8K0 413
UniProtKB:A3KNS3 413
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations