PUBLICATION
A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
- Authors
- Krauss, S., Concordet, J.P., and Ingham, P.W.
- ID
- ZDB-PUB-961014-632
- Date
- 1993
- Source
- Cell 75(7): 1431-1444 (Journal)
- Registered Authors
- Ingham, Philip, Krauss, Stefan
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- DNA Primers/chemistry
- Drosophila Proteins*
- Female
- Gene Expression
- Genes
- Hedgehog Proteins
- Male
- Molecular Sequence Data
- Morphogenesis
- Proteins/genetics*
- RNA, Messenger/genetics
- Sequence Alignment
- Sequence Homology, Amino Acid
- Zebrafish/embryology*
- PubMed
- 8269519 Full text @ Cell
Citation
Krauss, S., Concordet, J.P., and Ingham, P.W. (1993) A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos. Cell. 75(7):1431-1444.
Abstract
The segment polarity gene hedgehog (hh) encodes a novel signaling protein that mediates local cell-cell interactions in the developing Drosophila embryo. Here we describe the existence of an hh-related gene family in the zebrafish, Brachydanio rerio. One of these genes, sonic hedgehog (shh), is expressed in the notochord, floor plate, and posterior fin mesoderm, tissues associated with polarizing activities in various vertebrate embryos. The pattern of shh expression in zebra-fish mutants affecting axial structures, together with the consequences of its ectopic expression in normal embryos, is consistent with a role for shh in floor plate induction. By expressing shh in transgenic Drosophila embryos, we also demonstrate a strong functional conservation between the fish and fly hh genes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping