Gene
zmynd11
- ID
- ZDB-GENE-050522-301
- Name
- zinc finger, MYND-type containing 11
- Symbol
- zmynd11 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable methylated histone binding activity. Acts upstream of or within SMAD protein signal transduction and negative regulation of BMP signaling pathway. Predicted to be active in nucleus. Is expressed in brain; gut; head; immature eye; and trunk. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 30. Orthologous to human ZMYND11 (zinc finger MYND-type containing 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Sun et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb802 | Allele with one deletion | Exon 15 | Frameshift | CRISPR | |
| ihb803 | Allele with one insertion | Exon 15 | Frameshift | CRISPR | |
| la022956Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la022957Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa6776 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44159 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-zmynd11 | Sun et al., 2018 | |
| MO1-zmynd11 | N/A | Huang et al., 2013 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 30 | Alliance | Intellectual developmental disorder, autosomal dominant 30 | 616083 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Bromodomain | Bromodomain-like superfamily | PWWP domain | SAM domain-containing protein 1-like, WH domain | Zinc finger, FYVE/PHD-type | Zinc finger MYND domain-containing protein 11 | Zinc finger MYND domain-containing protein 11, PWWP domain | Zinc finger, MYND-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PG15 | InterPro | 621 | ||||||||||||
| UniProtKB:A0A2R8PVB4 | InterPro | 629 | ||||||||||||
| UniProtKB:Q08CT0 | InterPro | 640 | ||||||||||||
| UniProtKB:Q503P6 | InterPro | 85 | ||||||||||||
| UniProtKB:A0A8M9PXI9 | InterPro | 464 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
zmynd11-202
(1)
|
Ensembl | 3,901 nt | ||
| mRNA |
zmynd11-205
(1)
|
Ensembl | 4,994 nt | ||
| ncRNA |
zmynd11-002
(1)
|
Ensembl | 2,437 nt | ||
| ncRNA |
zmynd11-003
(1)
|
Ensembl | 853 nt | ||
| ncRNA |
zmynd11-004
(1)
|
Ensembl | 1,019 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-181H23 | ZFIN Curated Data | |
| Encodes | EST | fi38d06 | ||
| Encodes | cDNA | MGC:110370 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:152745 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077583 (1) | 2566 nt | ||
| Genomic | GenBank:BX571689 (2) | 154608 nt | ||
| Polypeptide | UniProtKB:A0A8M1NBV5 (1) | 640 aa |
- Sun, X., Chen, J., Zhang, Y., Munisha, M., Dougan, S., Sun, Y. (2018) Mga Modulates Bmpr1a Activity by Antagonizing Bs69 in Zebrafish. Frontiers in cell and developmental biology. 6:126
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wu, S., Roch, G., Cervini, L., Rivier, J., and Sherwood, N. (2008) Newly-identified receptors for PHI and GHRH-like peptide in zebrafish help to elucidate the mammalian secretin superfamily. Journal of molecular endocrinology. 41(5):343-366
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Wu, K.M., Huang, C.J., Hwang, S.P., and Chang, Y.S. (2006) Molecular cloning, expression and characterization of the zebrafish bram1 gene, a BMP receptor-associated molecule. Journal of Biomedical Science. 13(3):345-355
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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