Gene

clcn2c

ID
ZDB-GENE-050506-73
Name
chloride channel 2c
Symbol
clcn2c Nomenclature History
Previous Names
  • clc-2c (1)
  • im:6903943 (1)
  • si:ch211-229n1.3
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have voltage-gated chloride channel activity. Involved in chloride ion homeostasis. Localizes to cell junction. Is expressed in several structures, including extension; gill; ionocyte; mucus secreting cell; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 11 and primary hyperaldosteronism. Orthologous to human CLCN2 (chloride voltage-gated channel 2).
Genome Resources
Note
In pre-publication communications with Alejandro Barrallo Gimeno, it was determined that this gene will be called clcn2c in his upcoming publication.
Comparative Information
Expression
All Expression Data
17 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Wang et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With clcn2c Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
idiopathic generalized epilepsy 11 Alliance {Epilepsy, idiopathic generalized, susceptibility to, 11} 607628
idiopathic generalized epilepsy 11 Alliance {Epilepsy, juvenile absence, susceptibility to, 2} 607628
idiopathic generalized epilepsy 11 Alliance {Epilepsy, juvenile myoclonic, susceptibility to, 8} 607628
primary hyperaldosteronism Alliance Hyperaldosteronism, familial, type II 605635
Leukoencephalopathy with ataxia 615651
Associated With clcn2c Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR001807 Chloride channel, voltage gated
Family IPR050970 Voltage-gated chloride channel
Homologous_superfamily IPR014743 Chloride channel, core
Homologous_superfamily IPR046342 CBS domain superfamily
Domain Details Per Protein
Protein Length CBS domain superfamily Chloride channel, core Chloride channel, voltage gated Voltage-gated chloride channel
UniProtKB:E7FCE2 810
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA clcn2c-201 (1) Ensembl 2,755 nt
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-clcn2c Rabbit
  • IHC
  • WB
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations