header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-050420-319
Gene Name: WT1 transcription factor b
Gene Symbol: wt1b    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: si:ch211-160j6.3 (1), zgc:152697 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in glomerular visceral epithelial cell differentiation and pronephros development. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in several diseases, including Denys-Drash syndrome; Frasier syndrome; malignant mesothelioma; nephroblastoma; and nephrotic syndrome type 4. Is expressed in several structures, including eye; heart; intermediate mesoderm; pleuroperitoneal region; and podocyte. Orthologous to human WT1 (WT1 transcription factor).
Genome Resources: Alliance (1),  Gene:568416 (1),  Ensembl(GRCz11):ENSDARG00000007990 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
cu22 Small Deletion Unknown Unknown CRISPR
li14 Small Deletion Exon 2 Unknown CRISPR
ue402 Small Deletion Unknown Frameshift, Premature Stop CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-wt1b 1
CRISPR2-wt1b 2
CRISPR3-wt1b 1
CRISPR4-wt1b
1
MO1-wt1b N/A 2
MO2-wt1b N/A 1
MO6-wt1a,wt1b N/A 1
DISEASE ASSOCIATED WITH wt1b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Denys-Drash syndrome Alliance Denys-Drash syndrome 194080
Frasier syndrome Alliance Frasier syndrome 136680
malignant mesothelioma Alliance Mesothelioma, somatic 156240
nephroblastoma Alliance Wilms tumor, type 1 194070
nephrotic syndrome type 4 Alliance Nephrotic syndrome, type 4 256370
Meacham syndrome 608978
DISEASE ASSOCIATED WITH wt1b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process glomerular visceral epithelial cell differentiation (more)
Cellular Component nucleus (more)
Molecular Function metal ion binding (more)
GO Terms (all 8)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA wt1b-201 (1)    Ensembl 1389
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM wt1b
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(-2.6wt1b:EGFP) wt1b EGFP Danio rerio 1 3
tg(5xuas:wt1b,gfp,cryaa:ecfp) cryaaUAS ECFPGFPwt1b Danio rerio 1 4
Tg(5xUAS:wt1bDN,GFP) UAS GFPwt1b Danio rerio 0 1
Tg(wt1b:EGFP) wt1b EGFP Danio rerio 3 100
Tg(wt1b:GFP,col2a1a:mCherry) col2a1awt1b GFPmCherry Danio rerio 1 3
Tg(wt1b:mCherry) wt1b mCherry Danio rerio 1 3
MARKER RELATIONSHIPS
wt1b Contained in: [BAC] CH211-4L14 (1) (order this), CH211-160J6 (1) (order this)
wt1b Encodes: [cDNA] MGC:152697 (1) (order this), MGC:191893 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001039634 (1) 2221 bp
Genomic GenBank:BX248120 (1) 181815 bp
Select Tool
Polypeptide UniProtKB:Q1L884 (1) 412 aa
Sequence Clusters UniGene:91799 (1)
Sequence Information (all 22)
ORTHOLOGY for wt1b ( Chr: 18 )
CITATIONS (72)