Gene
wt1b
- ID
- ZDB-GENE-050420-319
- Name
- WT1 transcription factor b
- Symbol
- wt1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including fin regeneration; kidney development; and macrophage chemotaxis. Predicted to be located in cytoplasm and nuclear speck. Is expressed in several structures, including eye; heart; intermediate mesoderm; pleuroperitoneal region; and podocyte. Human ortholog(s) of this gene implicated in several diseases, including Denys-Drash syndrome; Frasier syndrome; malignant mesothelioma; nephroblastoma (multiple); and nephrotic syndrome type 4. Orthologous to human WT1 (WT1 transcription factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 45 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-wt1b | (2) | |
| CRISPR2-wt1b | (3) | |
| CRISPR3-wt1b | Charlton-Perkins et al., 2019 | |
| CRISPR4-wt1b | Charlton-Perkins et al., 2019 | |
| MO1-wt1b | N/A | (2) |
| MO2-wt1b | N/A | Perner et al., 2007 |
| MO6-wt1a,wt1b | N/A | Tomar et al., 2014 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Denys-Drash syndrome | Alliance | Denys-Drash syndrome | 194080 |
| Frasier syndrome | Alliance | Frasier syndrome | 136680 |
| malignant mesothelioma | Alliance | Mesothelioma, somatic | 156240 |
| nephroblastoma | Alliance | Wilms tumor, type 1 | 194070 |
| nephrotic syndrome type 4 | Alliance | Nephrotic syndrome, type 4 | 256370 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Wilm's tumour protein, N-terminal | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|
| UniProtKB:Q08CU4 | InterPro | 404 | |||
| UniProtKB:A0A8M2B680 | InterPro | 409 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(wt1b:EGFP) |
|
| 3 | (155) | |
| Tg(-2.6wt1b:EGFP) |
|
| 1 | (3) | |
| Tg(5xUAS:BGi-EGFP,wt1b(-KTS)-BGi,cryaa:ECFP) |
| 1 | (3) | ||
| Tg(5xUAS:BGi-EGFP,wt1b(+KTS)-BGi,cryaa:ECFP) |
| 1 | (3) | ||
| Tg(5xUAS:wt1bDN,GFP) |
|
| Zebrafish Nomenclature Committee | ||
| Tg(5xUAS:wt1b,GFP,cryaa:ECFP) |
| 1 | (4) | ||
| TgBAC(wt1b:Cre-2A-mCherry) |
|
| 1 | Weinberger et al., 2020 | |
| TgBAC(wt1b:GAL4FF) |
|
| 1 | (2) | |
| TgBAC(wt1b:H2B-Dendra2) |
|
| 1 | (2) | |
| TgBAC(wt1b:RTTA-2A-CreERT2) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-4L14 | ZFIN Curated Data | |
| Contained in | BAC | CH211-160J6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:152697 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191893 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001039634 (1) | 2208 nt | ||
| Genomic | GenBank:BX248120 (2) | 181815 nt | ||
| Polypeptide | UniProtKB:A0A8M2B680 (1) | 409 aa |
- Ahmed, I., Ziab, M., Da'as, S., Hasan, W., Jeya, S.P., Aliyev, E., Nisar, S., Bhat, A.A., Fakhro, K.A., Alshabeeb Akil, A.S. (2023) Network-based identification and prioritization of key transcriptional factors of diabetic kidney disease. Computational and structural biotechnology journal. 21:716730716-730
- Boezio, G.L.M., Zhao, S., Gollin, J., Priya, R., Mansingh, S., Guenther, S., Fukuda, N., Gunawan, F., Stainier, D.Y.R. (2022) The developing epicardium regulates cardiac chamber morphogenesis by promoting cardiomyocyte growth. Disease models & mechanisms. 16(5):
- Drummond, B.E., Chambers, B.E., Wesselman, H.M., Gibson, S., Arceri, L., Ulrich, M.N., Gerlach, G.F., Kroeger, P.T., Leshchiner, I., Goessling, W., Wingert, R.A. (2022) osr1 Maintains Renal Progenitors and Regulates Podocyte Development by Promoting wnt2ba via the Antagonism of hand2. Biomedicines. 10(11):
- Hopfenmüller, V.L., Perner, B., Reuter, H., Bates, T.J.D., Große, A., Englert, C. (2022) The Wilms Tumor Gene wt1a Contributes to Blood-Cerebrospinal Fluid Barrier Function in Zebrafish. Frontiers in cell and developmental biology. 9:809962
- Marques, I.J., Ernst, A., Arora, P., Vianin, A., Hetke, T., Sanz-Morejón, A., Naumann, U., Odriozola, A., Langa, X., Andrés-Delgado, L., Zuber, B., Torroja, C., Osterwalder, M., Simões, F., Englert, C., Mercader, N. (2022) WT1 transcription factor impairs cardiomyocyte specification and drives a phenotypic switch from myocardium to epicardium. Development (Cambridge, England). 149(6):
- Wasserman, A.H., Huang, A.R., Lewis-Israeli, Y.R., Dooley, M.D., Mitchell, A.L., Venkatesan, M., Aguirre, A. (2022) Oxytocin promotes epicardial cell activation and heart regeneration after cardiac injury. Frontiers in cell and developmental biology. 10:985298
- Xia, Y., Duca, S., Perder, B., Dündar, F., Zumbo, P., Qiu, M., Yao, J., Cao, Y., Harrison, M.R.M., Zangi, L., Betel, D., Cao, J. (2022) Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration. Nature communications. 13:77047704
- de Bakker, D.E.M., Bouwman, M., Dronkers, E., Simões, F.C., Riley, P.R., Goumans, M.J., Smits, A.M., Bakkers, J. (2021) Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte proliferation during zebrafish heart regeneration. Development (Cambridge, England). 148(19):
- Djenoune, L., Tomar, R., Dorison, A., Ghobrial, I., Schenk, H., Hegermann, J., Beverly-Staggs, L., Hidalgo-Gonzalez, A., Little, M.H., Drummond, I.A. (2021) Autonomous Calcium Signaling in Human and Zebrafish Podocytes Controls Kidney Filtration Barrier Morphogenesis. Journal of the American Society of Nephrology : JASN. 32(7):1697-1712
- Perens, E.A., Diaz, J.T., Quesnel, A., Askary, A., Crump, J.G., Yelon, D. (2021) osr1 couples intermediate mesoderm cell fate with temporal dynamics of vessel progenitor cell differentiation. Development (Cambridge, England). 148(15):
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