ZFIN ID: ZDB-GENE-050420-319
Gene Name: WT1 transcription factor b
Gene Symbol: wt1b    Nomenclature History

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Previous Names: si:ch211-160j6.3 (1), zgc:152697 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; fin regeneration; and macrophage chemotaxis. Predicted to localize to nucleus. Is expressed in several structures, including eye; heart; intermediate mesoderm; pleuroperitoneal region; and podocyte. Human ortholog(s) of this gene implicated in several diseases, including Denys-Drash syndrome; Frasier syndrome; malignant mesothelioma; nephroblastoma; and nephrotic syndrome type 4. Orthologous to human WT1 (WT1 transcription factor).
Genome Resources: Alliance (1),  Gene:568416 (1),  Ensembl(GRCz11):ENSDARG00000007990 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
cu22 Small Deletion Unknown Unknown CRISPR
li14 Small Deletion Exon 2 Frameshift, Premature Stop CRISPR
ue402 Small Deletion Unknown Frameshift, Premature Stop CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-wt1b 1
CRISPR2-wt1b 2
CRISPR3-wt1b 1
CRISPR4-wt1b
1
MO1-wt1b N/A 2
MO2-wt1b N/A 1
MO6-wt1a,wt1b N/A 1
DISEASE ASSOCIATED WITH wt1b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Denys-Drash syndrome Alliance Denys-Drash syndrome 194080
Frasier syndrome Alliance Frasier syndrome 136680
malignant mesothelioma Alliance Mesothelioma, somatic 156240
nephroblastoma Alliance Wilms tumor, type 1 194070
nephrotic syndrome type 4 Alliance Nephrotic syndrome, type 4 256370
Meacham syndrome 608978
DISEASE ASSOCIATED WITH wt1b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process glomerular visceral epithelial cell differentiation (more)
Cellular Component nucleus (more)
Molecular Function metal ion binding (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA wt1b-201 (1)    Ensembl 1389
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS
Addgene:135766
CONSTRUCTS WITH SEQUENCES FROM wt1b
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(-2.6wt1b:EGFP) wt1b EGFP Danio rerio 1 3
tg(5xuas:wt1b,gfp,cryaa:ecfp) cryaaUAS ECFPGFPwt1b Danio rerio 1 4
Tg(5xUAS:wt1bDN,GFP) UAS GFPwt1b Danio rerio 0 1
Tg(wt1b:EGFP) wt1b EGFP Danio rerio 3 107
tg(wt1b:gal4ff) wt1b GAL4FF Danio rerio 0 1
Tg(wt1b:GFP,col2a1a:mCherry) col2a1awt1b GFPmCherry Danio rerio 1 3
Tg(wt1b:mCherry) wt1b mCherry Danio rerio 1 3
tgbac(wt1b:rtta-2a-creert2) wt1b 2ACreERT2RTTA Danio rerio 0 1
MARKER RELATIONSHIPS
wt1b Contained in: [BAC] CH211-4L14 (1), CH211-160J6 (1)
wt1b Encodes: [cDNA] MGC:152697 (1), MGC:191893 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001039634 (1) 2221 nt
Genomic GenBank:BX248120 (1) 181815 nt
Select Tool
Polypeptide UniProtKB:Q1L884 (1) 412 aa
Sequence Information (all 21)
ORTHOLOGY for wt1b ( Chr: 18 )
CITATIONS (76)