wt1b

ID

ZDB-GENE-050420-319

Name

WT1 transcription factor b

Symbol

wt1b Nomenclature History

Previous Names

si:ch211-160j6.3 (1)
zgc:152697 (1)

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including fin regeneration; kidney development; and macrophage chemotaxis. Predicted to be located in cytoplasm and nuclear speck. Is expressed in several structures, including eye; heart; intermediate mesoderm; pleuroperitoneal region; and podocyte. Human ortholog(s) of this gene implicated in several diseases, including Denys-Drash syndrome; Frasier syndrome; malignant mesothelioma; nephroblastoma (multiple); and nephrotic syndrome type 4. Orthologous to human WT1 (WT1 transcription factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

46 figures from 21 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With wt1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Denys-Drash syndrome	Alliance	Denys-Drash syndrome	194080
Frasier syndrome	Alliance	Frasier syndrome	136680
malignant mesothelioma	Alliance	Mesothelioma, somatic	156240
nephroblastoma	Alliance	Wilms tumor, type 1	194070
nephrotic syndrome type 4	Alliance	Nephrotic syndrome, type 4	256370
		Meacham syndrome	608978