Gene

wt1b

ID
ZDB-GENE-050420-319
Name
WT1 transcription factor b
Symbol
wt1b Nomenclature History
Previous Names
  • si:ch211-160j6.3 (1)
  • zgc:152697 (1)
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including fin regeneration; kidney development; and macrophage chemotaxis. Predicted to be located in nucleus. Is expressed in several structures, including eye; heart; intermediate mesoderm; pleuroperitoneal region; and podocyte. Human ortholog(s) of this gene implicated in several diseases, including Denys-Drash syndrome; Frasier syndrome; malignant mesothelioma; nephroblastoma (multiple); and nephrotic syndrome type 4. Orthologous to human WT1 (WT1 transcription factor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
46 figures from 21 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With wt1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Denys-Drash syndrome Alliance Denys-Drash syndrome 194080
Frasier syndrome Alliance Frasier syndrome 136680
malignant mesothelioma Alliance Mesothelioma, somatic 156240
nephroblastoma Alliance Wilms tumor, type 1 194070
nephrotic syndrome type 4 Alliance Nephrotic syndrome, type 4 256370
1 - 5 of 6 Show all
Associated With wt1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000976 Wilm's tumour protein, N-terminal
Domain IPR013087 Zinc finger C2H2-type
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
1 - 3 of 3
Domain Details Per Protein
Protein Additional Resources Length Wilm's tumour protein, N-terminal Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:Q08CU4 InterPro 404
UniProtKB:A0A8M2B680 InterPro 409
UniProtKB:A0A8M1N8C0 InterPro 404
1 - 3 of 3
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA wt1b-201 (1)
Ensembl
Ensembl 1,389 nt
ZFIN BLAST
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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