Gene

crebbpa

ID

ZDB-GENE-050208-439

Name

CREB binding protein a

Symbol

crebbpa Nomenclature History

Previous Names

CBP-B (1)
crebbp
CREBBPb (1)
si:dkey-206l1.6
si:dkey-44g23.1

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have histone acetyltransferase activity; transcription coactivator activity; and zinc ion binding activity. Involved in hematopoietic progenitor cell differentiation. Localizes to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Is expressed in several structures, including blastoderm; blastodisc; digestive system; segmental plate; and solid lens vesicle. Orthologous to human CREBBP (CREB binding protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

dq017641 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Batut et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With crebbpa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Rubinstein-Taybi syndrome	Alliance	Rubinstein-Taybi syndrome 1	180849
		Menke-Hennekam syndrome 1	618332

Associated With crebbpa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018359	Bromodomain, conserved site
Domain	IPR000197	Zinc finger, TAZ-type
Domain	IPR000433	Zinc finger, ZZ-type
Domain	IPR001487	Bromodomain
Domain	IPR003101	Coactivator CBP, KIX domain
Domain	IPR010303	CREB-binding protein/p300, atypical RING domain
Domain	IPR014744	Nuclear receptor coactivator, CREB-bp-like, interlocking
Domain	IPR031162	CBP/p300-type histone acetyltransferase domain
Family	IPR013178	Histone acetyltransferase Rtt109/CBP
Homologous_superfamily	IPR009110	Nuclear receptor coactivator, interlocking
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR035898	TAZ domain superfamily
Homologous_superfamily	IPR036427	Bromodomain-like superfamily
Homologous_superfamily	IPR036529	Coactivator CBP, KIX domain superfamily
Homologous_superfamily	IPR037073	Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily
Homologous_superfamily	IPR038547	CBP/p300, atypical RING domain superfamily
Homologous_superfamily	IPR043145	Zinc finger, ZZ-type superfamily

Domain Details Per Protein

Protein	Length	Bromodomain	Bromodomain, conserved site	Bromodomain-like superfamily	CBP/p300, atypical RING domain superfamily	CBP/p300-type histone acetyltransferase domain	Coactivator CBP, KIX domain	Coactivator CBP, KIX domain superfamily	CREB-binding protein/p300, atypical RING domain	Histone acetyltransferase Rtt109/CBP	Nuclear receptor coactivator, CREB-bp-like, interlocking	Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily	Nuclear receptor coactivator, interlocking	TAZ domain superfamily	Zinc finger, RING/FYVE/PHD-type	Zinc finger, TAZ-type	Zinc finger, ZZ-type	Zinc finger, ZZ-type superfamily
UniProtKB:A0A8M9PDM0 InterPro	2346
UniProtKB:A0A8M9PQB0 InterPro	2264
UniProtKB:A0A0R4IPF2 InterPro	2349
UniProtKB:A0A2R8Q4T2 InterPro	2267
UniProtKB:A0A8M9Q3D9 InterPro	2347
UniProtKB:A0A8M2B8L6 InterPro	2350

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	crebbpa-201 (1) Ensembl	Ensembl	8,544 nt	Select Tool
mRNA	crebbpa-202 (1) Ensembl	Ensembl	9,187 nt	Select Tool ZFIN BLAST
mRNA	crebbpa-203 (1) Ensembl	Ensembl	8,941 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab3-crebbpa	polyclonal	crebbpa		Rabbit	IHC WB		1
Ab2-crebbpa	polyclonal	crebbpa		Rabbit	IHC WB		1
Ab1-crebbp	polyclonal	crebbpa	IgG	Rabbit	IHC	Santa Cruz Biotechnology, Inc.	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations