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Gene

crebbpa

ID
ZDB-GENE-050208-439
Name
CREB binding protein a
Symbol
crebbpa Nomenclature History
Previous Names
  • CBP-B (1)
  • crebbp
  • CREBBPb (1)
  • si:dkey-206l1.6
  • si:dkey-44g23.1
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to enable chromatin DNA binding activity; histone acetyltransferase activity; and transcription coactivator activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including blastoderm; blastodisc; digestive system; segmental plate; and solid lens vesicle. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Batut et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With crebbpa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Rubinstein-Taybi syndrome Alliance Rubinstein-Taybi syndrome 1 180849
Menke-Hennekam syndrome 1 618332
Associated With crebbpa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018359 Bromodomain, conserved site
Domain IPR000197 Zinc finger, TAZ-type
Domain IPR000433 Zinc finger, ZZ-type
Domain IPR001487 Bromodomain
Domain IPR003101 Coactivator CBP, KIX domain
Domain IPR010303 CREB-binding protein/p300, atypical RING domain
Domain IPR014744 Nuclear receptor coactivator, CREB-bp-like, interlocking
Domain IPR031162 CBP/p300-type histone acetyltransferase domain
Family IPR013178 Histone acetyltransferase Rtt109/CBP
Homologous_superfamily IPR009110 Nuclear receptor coactivator, interlocking
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR035898 TAZ domain superfamily
Homologous_superfamily IPR036427 Bromodomain-like superfamily
Homologous_superfamily IPR036529 Coactivator CBP, KIX domain superfamily
Homologous_superfamily IPR037073 Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily
Homologous_superfamily IPR038547 CBP/p300, atypical RING domain superfamily
Homologous_superfamily IPR043145 Zinc finger, ZZ-type superfamily
Domain Details Per Protein
Protein Length Bromodomain Bromodomain, conserved site Bromodomain-like superfamily CBP/p300, atypical RING domain superfamily CBP/p300-type histone acetyltransferase domain Coactivator CBP, KIX domain Coactivator CBP, KIX domain superfamily CREB-binding protein/p300, atypical RING domain Histone acetyltransferase Rtt109/CBP Nuclear receptor coactivator, CREB-bp-like, interlocking Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily Nuclear receptor coactivator, interlocking TAZ domain superfamily Zinc finger, RING/FYVE/PHD-type Zinc finger, TAZ-type Zinc finger, ZZ-type Zinc finger, ZZ-type superfamily
UniProtKB:Q1L665 238
UniProtKB:A0A0R4INM9 2312
UniProtKB:A0A0R4IPF2 2349
UniProtKB:A0A2R8Q4T2 2267
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-crebbpa polyclonal Rabbit
  • IHC
  • WB
1
Ab2-crebbpa polyclonal Rabbit
  • IHC
  • WB
1
Ab1-crebbp polyclonal IgG Rabbit
  • IHC
Santa Cruz Biotechnology, Inc.
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations