Gene

dchs1b

ID
ZDB-GENE-050208-41
Name
dachsous cadherin-related 1b
Symbol
dchs1b Nomenclature History
Previous Names
  • dchs1
  • im:7136458 (1)
  • im:7156059
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Is predicted to enable cadherin binding activity and calcium ion binding activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell morphogenesis; and cell-cell junction organization. Acts upstream of or within several processes, including atrioventricular canal development; cortical granule exocytosis; and mitotic cleavage furrow formation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of catenin complex. Is expressed in several structures, including blastomere; heart; mesoderm; musculature system; and retina. Human ortholog(s) of this gene implicated in Van Maldergem syndrome 1 and mitral valve prolapse. Orthologous to human DCHS1 (dachsous cadherin-related 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dchs1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
mitral valve prolapse Alliance Mitral valve prolapse 2 607829
Van Maldergem syndrome 1 Alliance Van Maldergem syndrome 1 601390
Associated With dchs1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020894 Cadherin conserved site
Domain IPR002126 Cadherin-like
Homologous_superfamily IPR015919 Cadherin-like superfamily
Domain Details Per Protein
Protein Length Cadherin conserved site Cadherin-like Cadherin-like superfamily
UniProtKB:F1QGX1 3298
UniProtKB:Q5CZT3 436
UniProtKB:E9QEN9 274
UniProtKB:F1QXA3 921
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations