Gene
lrp2a
- ID
- ZDB-GENE-050119-2
- Name
- low density lipoprotein receptor-related protein 2a
- Symbol
- lrp2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable hormone binding activity. Acts upstream of or within several processes, including glomerular filtration; regulation of receptor-mediated endocytosis; and renal absorption. Predicted to be located in several cellular components, including axon; dendrite; and endosome lumen. Predicted to be part of receptor complex. Predicted to be active in apical plasma membrane. Is expressed in several structures, including gut epithelium; nervous system; otic vesicle; pronephros; and radial glial cell. Used to study myopia. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 28 figures from 10 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Donnai-Barrow syndrome | Alliance | Donnai-Barrow syndrome | 222448 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
myopia | lrp2amw90/mw90 | standard conditions | Collery et al., 2019 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
Conserved_site | IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
Domain | IPR000742 | EGF-like domain |
Domain | IPR001881 | EGF-like calcium-binding domain |
Domain | IPR026823 | Complement Clr-like EGF domain |
Family | IPR051221 | Low-density lipoprotein receptor-related |
Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
Homologous_superfamily | IPR011042 | Six-bladed beta-propeller, TolB-like |
Homologous_superfamily | IPR036055 | LDL receptor-like superfamily |
PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Repeat | IPR000033 | LDLR class B repeat |
Repeat | IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
Domain Details Per Protein
Protein | Additional Resources | Length | Complement Clr-like EGF domain | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | LDLR class B repeat | LDL receptor-like superfamily | Low-density lipoprotein (LDL) receptor class A, conserved site | Low-density lipoprotein (LDL) receptor class A repeat | Low-density lipoprotein receptor-related | Six-bladed beta-propeller, TolB-like |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:E0AE56 | InterPro | 4673 | ||||||||||||
UniProtKB:A0A8M1NV12 | InterPro | 4673 | ||||||||||||
UniProtKB:A0AB32TUV2 | InterPro | 4635 | ||||||||||||
UniProtKB:A0AB32U0H0 | InterPro | 4654 | ||||||||||||
UniProtKB:A0AB32U1G2 | InterPro | 4673 | ||||||||||||
UniProtKB:A0AB32U1I3 | InterPro | 4649 | ||||||||||||
UniProtKB:A0AB32U2M8 | InterPro | 4668 |
Interactions and Pathways
Plasmids
No data available