Gene

lrp2a

ID
ZDB-GENE-050119-2
Name
low density lipoprotein receptor-related protein 2a
Symbol
lrp2a Nomenclature History
Previous Names
  • lrp2 (1)
  • gp330b
  • im:680590
  • megalin (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have hormone binding activity. Involved in receptor-mediated endocytosis and renal absorption. Predicted to localize to apical plasma membrane and receptor complex. Is expressed in several structures, including gut epithelium; nervous system; otic vesicle; pronephros; and radial glial cell. Used to study myopia. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
18 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
23 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lrp2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Donnai-Barrow syndrome Alliance Donnai-Barrow syndrome 222448
Associated With lrp2a Via Experimental Models
Human Disease Fish Conditions Citations
myopia lrp2amw90/mw90 standard conditions Collery et al., 2019
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Conserved_site IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR026823 Complement Clr-like EGF domain
Domain IPR032485 Domain of unknown function DUF5050
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR011042 Six-bladed beta-propeller, TolB-like
Homologous_superfamily IPR036055 LDL receptor-like superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Repeat IPR000033 LDLR class B repeat
Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Domain Details Per Protein
Protein Length Complement Clr-like EGF domain Domain of unknown function DUF5050 EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily LDLR class B repeat LDL receptor-like superfamily Low-density lipoprotein (LDL) receptor class A, conserved site Low-density lipoprotein (LDL) receptor class A repeat Six-bladed beta-propeller, TolB-like
UniProtKB:A0A0R4IVD8 4652
UniProtKB:A0A0R4IAG0 4673
UniProtKB:E0AE56 4673
UniProtKB:Q1A3D5 85
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations