Gene

lrp2a

ID
ZDB-GENE-050119-2
Name
low density lipoprotein receptor-related protein 2a
Symbol
lrp2a Nomenclature History
Previous Names
  • lrp2 (1)
  • gp330b
  • im:680590
  • megalin (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Is predicted to enable hormone binding activity. Acts upstream of or within receptor-mediated endocytosis and renal absorption. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Is expressed in several structures, including gut epithelium; nervous system; otic vesicle; pronephros; and radial glial cell. Used to study myopia. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
21 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
27 figures from 9 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lrp2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Donnai-Barrow syndrome Alliance Donnai-Barrow syndrome 222448
Associated With lrp2a Via Experimental Models
Human Disease Fish Conditions Citations
myopia lrp2amw90/mw90 standard conditions Collery et al., 2019
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Conserved_site IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR026823 Complement Clr-like EGF domain
Domain IPR032485 Domain of unknown function DUF5050
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR011042 Six-bladed beta-propeller, TolB-like
Homologous_superfamily IPR036055 LDL receptor-like superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Repeat IPR000033 LDLR class B repeat
Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Domain Details Per Protein
Protein Length Complement Clr-like EGF domain Domain of unknown function DUF5050 EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily LDLR class B repeat LDL receptor-like superfamily Low-density lipoprotein (LDL) receptor class A, conserved site Low-density lipoprotein (LDL) receptor class A repeat Six-bladed beta-propeller, TolB-like
UniProtKB:A0A0R4IAG0 4673
UniProtKB:E0AE56 4673
UniProtKB:Q1A3D5 85
UniProtKB:A0A0R4IVD8 4652
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations