ZFIN Gene: lrp2a

ZFIN ID: ZDB-GENE-050119-2

ZFIN ID: ZDB-GENE-050119-2

Gene Name:

low density lipoprotein receptor-related protein 2a

Gene Symbol:

lrp2a

Sequence Ontology ID :

SO:0000704

Previous Names:

lrp2 (1), gp330b, im:680590, megalin (1)

Location:

Chr: 9 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have calcium ion binding activity. Involved in receptor-mediated endocytosis and renal absorption. Predicted to localize to the integral component of membrane. Human ortholog(s) of this ...

GENE EXPRESSION
All Expression Data:	18 figures from 7 publications
Wild-type Stages, Structures:	Segmentation:14-19 somites (16.0h-19.0h) to Juvenile:Days 30-44 (30d-45d, 10 mm, adult fins/pigment)
	ciliary zone diencephalon dorsal telencephalon anterior side floor plate forebrain forebrain ventricle gut epithelium inner ear midbrain neural tube otic placode otic vesicle pronephric duct anterior region pronephric duct proximal region pronephric duct pronephric proximal convoluted tubule pronephric tubule pronephros proximal region pronephros radial glial cell retinal pigmented epithelium ventricular system anatomical surface ventricular system whole organism

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la016624Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la027052Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
mw1	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
p5bnc	Point Mutation	Unknown	Premature Stop	ENU
sa25	Point Mutation	Unknown	Splice Site	ENU
sa17023	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa18967	Point Mutation	Unknown	Splice Site	ENU
sa21599	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa21600	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa25440	Point Mutation	Unknown	Premature Stop	ENU
sa34763	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa34764	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa34765	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa34766	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa38765	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa41550	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa41551	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Targeting reagents:

MO1-lrp2a (1)
MO2-lrp2a (1)

PHENOTYPE

Data:

21 figures from 6 publications

Observed in:

DISEASE ASSOCIATED WITH lrp2a HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
Donnai-Barrow syndrome	Donnai-Barrow syndrome	222448

DISEASE ASSOCIATED WITH lrp2a VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	receptor-mediated endocytosis (more)
Cellular Component	integral component of membrane (more)
Molecular Function	calcium ion binding (more)

GO Terms (all 5)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR000033 (1) InterPro:IPR000152 (1) InterPro:IPR000742 (1) InterPro:IPR001881 (1) InterPro:IPR002172 (1) InterPro:IPR009030 (1) InterPro:IPR011042 (1) InterPro:IPR013032 (1) InterPro:IPR018097 (1) InterPro:IPR023415 (1) InterPro:IPR026823 (1) InterPro:IPR032485 (1) InterPro:IPR036055 (1)	PROSITE:PS00010 (1) PROSITE:PS00022 (1) PROSITE:PS01186 (1) PROSITE:PS01187 (1) PROSITE:PS01209 (1) PROSITE:PS50026 (1) PROSITE:PS50068 (1) PROSITE:PS51120 (1)	Pfam:PF00057 (1) Pfam:PF00058 (1) Pfam:PF07645 (1) Pfam:PF12662 (1) Pfam:PF16472 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	lrp2a-202 (1)	17239	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Withdrawn Transcripts
mRNA	lrp2-001 (1)	9277	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

SignaFish

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM lrp2a No data available

MARKER RELATIONSHIPS

lrp2aContained in:	[BAC] CH73-81D5 (1) (order this), CH211-121K8 (1) (order this) [Fosmid] CH1073-311N13 (1) (order this), CH1073-380O14 (1) (order this)
lrp2aContains:	[STS] zfishfos432h10.q1k (1)
lrp2aEncodes:	[EST] IMAGE:680590 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_001194987 (1)	14283bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX927361 (1)	177986bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A0R4IAG0 (1)	4673aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:86548 (1)

Sequence Information (all 26)

OTHER lrp2a GENE PAGES

Alliance (1)

Gene:568184 (1)

VEGA:OTTDARG00000036529 (1)

Ensembl(GRCz11):ENSDARG00000102506 (1)

ORTHOLOGY for lrp2a (Chr: 9)

CITATIONS (41)

{{control.fieldName}} Edit

Attributions

Add new Alias

Attributions for Alias: {{control.newAlias}}

Delete Alias: