Gene

tasor2

ID

ZDB-GENE-041111-225

Name

transcription activation suppressor family member 2

Symbol

tasor2 Nomenclature History

Previous Names

fam208b
im:7145096 (1)
si:ch211-204d2.5 (1)
wu:fb95d10
wu:fc15g07

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to act upstream of or within negative regulation of gene expression, epigenetic. Predicted to be active in nucleoplasm. Orthologous to human TASOR2 (transcription activation suppressor family member 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7145096 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa9993	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa16911	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa21207	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa38672	Allele with one point mutation	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa41133	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa41134	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With tasor2 Human Ortholog

No data available

Associated With tasor2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR022188	TASOR, DUF3715
Family	IPR046432	TASOR

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M2BE90	InterPro	2880
UniProtKB:A0A8M3BBL9	InterPro	2967
UniProtKB:A0A1L1QZC7	InterPro	3025

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 8

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	fam208b-202 (1) Ensembl	Ensembl	10,810 nt	Select Tool ZFIN BLAST
mRNA	fam208b-203 (1) Ensembl	Ensembl	10,874 nt	Select Tool ZFIN BLAST
ncRNA	ottdart00000034851 (1) Ensembl	Ensembl	860 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH211-204D2	CR847826	ZFIN Curated Data
Encodes	EST	fb95d10	AI584547 AI585197
Encodes	EST	fc15g07	AI641558 AI657615
Encodes	EST	IMAGE:7145096	CK682941	Thisse et al., 2004

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_009303785 (1)	10290 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR847826 (1)	150519 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A1L1QZC7 (1)	3025 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	TASOR2	10	Ensembl:ENSG00000108021 Gene:54906 HGNC:23484	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Tasor2	13	Ensembl:ENSMUSG00000033799 Gene:105203 MGI:2145274	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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