Gene
myo3a
- ID
- ZDB-GENE-041026-4
- Name
- myosin IIIA
- Symbol
- myo3a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable microfilament motor activity and protein serine/threonine kinase activity. Predicted to be involved in positive regulation of filopodium assembly; regulation of actin filament length; and sensory perception of sound. Predicted to act upstream of or within protein phosphorylation and visual perception. Predicted to be located in cell projection; cytoplasm; and cytoskeleton. Predicted to be part of myosin complex. Predicted to be active in filopodium tip; photoreceptor inner segment; and stereocilium tip. Is expressed in axis; notochord; photoreceptor inner segment layer; polster; and retina. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 90 and autosomal recessive nonsyndromic deafness 30. Orthologous to human MYO3A (myosin IIIA).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu463 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 90 | Alliance | Deafness, autosomal dominant 90 | 620722 |
| autosomal recessive nonsyndromic deafness 30 | Alliance | Deafness, autosomal recessive 30 | 607101 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001609 | Myosin head, motor domain-like |
| Domain | IPR036083 | Class III myosin, motor domain |
| Family | IPR052409 | Myosin-III family with kinase activity |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | Class III myosin, motor domain | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin head, motor domain-like | Myosin-III family with kinase activity | P-loop containing nucleoside triphosphate hydrolase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q90XG6
|
1775 |
Interactions and Pathways
No data available
Plasmids
No data available