Gene
nomo
- ID
- ZDB-GENE-040826-3
- Name
- nodal modulator
- Symbol
- nomo Nomenclature History
- Previous Names
-
- loc283820
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable carbohydrate binding activity. Involved in cartilage development; determination of left/right asymmetry in lateral mesoderm; and negative regulation of nodal signaling pathway. Acts upstream of or within adult locomotory behavior; regulation of signal transduction; and social behavior. Located in endoplasmic reticulum membrane. Is expressed in several structures, including heart; liver; mesoderm; nervous system; and pleuroperitoneal region. Used to study autistic disorder.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa7035 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10937 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15655 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa26715 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa26716 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33836 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf3106 | Allele with one delins | Unknown | Unknown | CRISPR | |
| zf3952 | Allele with one deletion | Exon 7 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nomo | Cao et al., 2018 | |
| CRISPR2-nomo | Cao et al., 2018 | |
| CRISPR3-nomo | Zhang et al., 2024 |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| autistic disorder | nomozf3952/zf3952 | standard conditions | Zhang et al., 2024 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR019008 | ER membrane protein complex subunit 7, beta-sandwich domain |
| Domain | IPR055073 | NOMO-like, ninth beta-sandwich domain |
| Domain | IPR055074 | NOMO, second beta-sandwich domain |
| Domain | IPR055075 | NOMO-like, N-terminal beta-sandwich domain |
| Family | IPR051417 | Serine-Aspartate Repeat-Containing |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Carbohydrate-binding-like fold | ER membrane protein complex subunit 7, beta-sandwich domain | NOMO-like, ninth beta-sandwich domain | NOMO-like, N-terminal beta-sandwich domain | NOMO, second beta-sandwich domain | Serine-Aspartate Repeat-Containing |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:X1WEJ6 | InterPro | 1208 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-265A11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_002662315 (1) | 4379 nt | ||
| Genomic | GenBank:CR762392 (2) | 203490 nt | ||
| Polypeptide | UniProtKB:X1WEJ6 (1) | 1208 aa |
No data available
- Zhang, Q., Li, F., Li, T., Lin, J., Jian, J., Zhang, Y., Chen, X., Liu, T., Gou, S., Zhang, Y., Liu, X., Ji, Y., Wang, X., Li, Q. (2024) Nomo1 deficiency causes autism-like behavior in zebrafish. EMBO reports. 25(2):570-592
- Cao, L., Li, L., Li, Y., Zhuang, J., Chen, Y., Luo, S., Wang, Y., Shi, Y., Chen, J., Gao, J., Zhu, X., Wan, Y., Li, F., Yuan, W., Mo, X., Ye, X., Wang, X., Zhou, Z., Dai, G., Jiang, Z., Zhu, P., Wu, X., Fan, X. (2018) Loss of the Nodal modulator Nomo results in chondrodysplasia in zebrafish. Current Molecular Medicine. 18(7):448-458
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Dettmer, U., Kuhn, P.H., Abou-Ajram, C., Lichtenthaler, S.F., Krueger, M., Kremmer, E., Haass, C., and Haffner, C. (2010) Transmembrane Protein 147 (TMEM147) Is a Novel Component of the Nicalin-NOMO Protein Complex. The Journal of biological chemistry. 285(34):26174-26181
- Haffner, C., and Haass, C. (2006) Cellular Functions of gamma-Secretase-Related Proteins. Neuro-degenerative Diseases. 3(4-5):284-289
- Haffner, C., and Haass, C. (2004) The Biochemical and Genetic Odyssey to the Function of a Nicastrin-Like Protein. Neuro-degenerative Diseases. 1(4-5):192-195
- Haffner, C., Frauli, M., Topp, S., Irmler, M., Hofmann, K., Regula, J.T., Bally-Cuif, L., and Haass, C. (2004) Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. The EMBO journal. 23(15):3041-3050
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