Gene
aurka
- ID
- ZDB-GENE-040801-161
- Name
- aurora kinase A
- Symbol
- aurka Nomenclature History
- Previous Names
-
- fb37c10
- fc02c02
- wu:fb37c10
- wu:fc02c02
- zgc:100912
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have histone serine kinase activity. Involved in mitotic cell cycle. Predicted to localize to microtubule cytoskeleton. Is expressed in several structures, including caudal fin; immature eye; nervous system; somite; and spinal cord neural tube. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; and uterine cancer. Orthologous to human AURKA (aurora kinase A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Jeon et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
colorectal cancer | Alliance | {Colon cancer, susceptibility to} | 114500 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR030611 | Aurora kinase A |
Family | IPR030616 | Aurora kinase |
Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
Protein | Length | Aurora kinase | Aurora kinase A | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
---|---|---|---|---|---|---|---|
UniProtKB:F1QEM3
|
405 | ||||||
UniProtKB:F8W4T4
|
289 | ||||||
UniProtKB:Q6DBZ4
|
405 |
Interactions and Pathways
No data available
Plasmids
No data available