Gene

aurka

ID
ZDB-GENE-040801-161
Name
aurora kinase A
Symbol
aurka Nomenclature History
Previous Names
  • fb37c10
  • fc02c02
  • wu:fb37c10
  • wu:fc02c02
  • zgc:100912
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have histone serine kinase activity. Involved in mitotic cell cycle. Predicted to localize to condensed nuclear chromosome, centromeric region and microtubule cytoskeleton. Is expressed in several structures, including caudal fin; immature eye; nervous system; somite; and spinal cord neural tube. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; and uterine cancer. Orthologous to human AURKA (aurora kinase A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Jeon et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With aurka Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Colon cancer, susceptibility to} 114500
Associated With aurka Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR030611 Aurora kinase A
Family IPR030616 Aurora kinase-like
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Aurora kinase A Aurora kinase-like Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:Q6DBZ4 405
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA aurka-201 (1) Ensembl 1732 nt
mRNA aurka-202 (1) Havana 1098 nt
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-aurka polyclonal Mouse
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations