Gene

tph2

ID
ZDB-GENE-040624-4
Name
tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)
Symbol
tph2 Nomenclature History
Previous Names
  • tph2a (1)
  • tphR (1)
  • wu:fq15a04
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have tryptophan 5-monooxygenase activity. Involved in regulation of hematopoietic stem cell differentiation. Predicted to localize to neuron projection. Is expressed in brain and neurons. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; major depressive disorder; and panic disorder. Orthologous to human TPH2 (tryptophan hydroxylase 2).
Genome Resources
Note
None
Expression
All Expression Data
33 figures from 26 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tph2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
endogenous depression Alliance {Unipolar depression, susceptibility to} 608516
{Attention deficit-hyperactivity disorder, susceptibility to, 7} 613003
Associated With tph2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018301 Aromatic amino acid hydroxylase, iron/copper binding site
Domain IPR002912 ACT domain
Domain IPR019774 Aromatic amino acid hydroxylase, C-terminal
Domain IPR041904 Tryptophan 5-hydroxylase, catalytic domain
Family IPR001273 Aromatic amino acid hydroxylase
Family IPR005963 Tryptophan 5-monooxygenase
Family IPR019773 Tyrosine 3-monooxygenase-like
Homologous_superfamily IPR036329 Aromatic amino acid monoxygenase, C-terminal domain superfamily
Homologous_superfamily IPR036951 Aromatic amino acid hydroxylase superfamily
Domain Details Per Protein
Protein Length ACT domain Aromatic amino acid hydroxylase Aromatic amino acid hydroxylase, C-terminal Aromatic amino acid hydroxylase, iron/copper binding site Aromatic amino acid hydroxylase superfamily Aromatic amino acid monoxygenase, C-terminal domain superfamily Tryptophan 5-hydroxylase, catalytic domain Tryptophan 5-monooxygenase Tyrosine 3-monooxygenase-like
UniProtKB:Q6IWP5 500
UniProtKB:B3DH34 492
UniProtKB:Q1LUE4 500
UniProtKB:Q75V71 473
UniProtKB:A0A0R4ILE6 500
UniProtKB:Q1LUE3 473
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-tph2 monoclonal IgG2a Rat
  • IHC
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations