Gene
tph2
- ID
- ZDB-GENE-040624-4
- Name
- tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)
- Symbol
- tph2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable tryptophan 5-monooxygenase activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation. Predicted to be active in neuron projection. Is expressed in brain and neurons. Human ortholog(s) of this gene implicated in autistic disorder; major depressive disorder; and panic disorder. Orthologous to human TPH2 (tryptophan hydroxylase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 39 figures from 31 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| melancholic depression | Alliance | {Unipolar depression, susceptibility to} | 608516 |
| {?Attention deficit-hyperactivity disorder, susceptibility to, 7} | 613003 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018301 | Aromatic amino acid hydroxylase, iron/copper binding site |
| Domain | IPR002912 | ACT domain |
| Domain | IPR019774 | Aromatic amino acid hydroxylase, C-terminal |
| Domain | IPR041904 | Tryptophan 5-hydroxylase, catalytic domain |
| Family | IPR001273 | Aromatic amino acid hydroxylase |
| Family | IPR005963 | Tryptophan 5-monooxygenase |
| Family | IPR019773 | Tyrosine 3-monooxygenase-like |
| Homologous_superfamily | IPR036329 | Aromatic amino acid monoxygenase, C-terminal domain superfamily |
| Homologous_superfamily | IPR036951 | Aromatic amino acid hydroxylase superfamily |
| Homologous_superfamily | IPR045865 | ACT-like domain |
Domain Details Per Protein
| Protein | Length | ACT domain | ACT-like domain | Aromatic amino acid hydroxylase | Aromatic amino acid hydroxylase, C-terminal | Aromatic amino acid hydroxylase, iron/copper binding site | Aromatic amino acid hydroxylase superfamily | Aromatic amino acid monoxygenase, C-terminal domain superfamily | Tryptophan 5-hydroxylase, catalytic domain | Tryptophan 5-monooxygenase | Tyrosine 3-monooxygenase-like |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1P7E6
|
546 | ||||||||||
|
UniProtKB:Q1LUE3
|
473 |
Interactions and Pathways
No data available
Plasmids
No data available